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Thread: Multiple STRs

  1. #1
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    Multiple STRs

    Hi all
    I'm currently R-fgc 3222. Comparing my STRs on the internet and awaiting y-500 results.
    I have some extra values.

    DYS459 = 9-9-9 compared to only 2 values/integers
    DYS464 = 15-15-15-16-17-17 compared to only 4 values/integers.
    CDY = 37-38-38 compared to only 2 values/integers

    Does anyone out there share these? Opinions on them.

    Thanks, Ray
    Last edited by Razr795; 01-26-2019 at 05:22 PM.

  2. #2
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    R1b-L21 L513*

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    Quote Originally Posted by Razr795 View Post
    Hi all
    I'm currently R-fgc 3222. Comparing my STRs on the internet and awaiting y-500 results.
    I have some extra values.

    DYS459 = 9-9-9 compared to only 2 values/integers
    DYS464 = 15-15-15-16-17-17 compared to only 4 values/integers.
    CDY = 37-38-38 compared to only 2 values/integers

    Does anyone out there share these? Opinions on them.

    Thanks, Ray
    It’s not uncommon to have extra values on these multi-copy markers. These three are actually linked together, they all appear on the same palindromic arm of the Y chromosome and can be affected by RecLOHs. I believe when they all show extra markers it’s considered to all have been caused by one mutation event and genetic distance is only increased by 1 (for all three, not 1 per marker).

    It’s been awhile since I’ve looked at how these are treated but I believe your original ancestral markers would be considered to be 459=9-9, 464=15-16-17-17, and CDY=37-38, and then one RecLOH would have created ALL the additional markers. I’m fuzzy on 464 mostly, it’s special in that it’s reported in a reordered low-to-high fashion so the 2 17s are not the extra markers, they’re just the higher values, and your ancestral value should be either 15-16-17-17 or 15-15-16-17.

    If you search for “multicopy STR markers” there are a lot of webpages that explain these in varying degrees of detail.

  3. The Following 2 Users Say Thank You to Dave-V For This Useful Post:

     Razr795 (01-27-2019),  rms2 (01-26-2019)

  4. #3
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    Thank you Dave-V.
    Last edited by Razr795; 01-27-2019 at 03:41 PM.

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