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Thread: Big Y-700/Yfull

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    Big Y-700/Yfull

    I understand that Big Y-700 has a significant increase in coverage over Big Y-500. My question is how much of that increased coverage affects Yfull’s analysis? Will the age estimations that Yfull uses need to be adjusted to differentiate between Big Y-500 and Big Y-700 kits?
    I1> DF29> Z58> Z59> Z2041> Z2040> Z382> S26361> S16414> FGC24354> FGC24357> FGC24356> S10350> FGC75802> Y125947> S21197> BY149414> BY188003> BY188570

    YFull id: YF15884

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    As long as the original Big Y remains the largest contribution of data in the set, all age calculations are limited to those regions. If you read Adamov’s paper that the process originally was developed for, you will learn why.

    BY700 will be most useful for locating new intermediate structures until that time.

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    Quote Originally Posted by JamesKane View Post
    As long as the original Big Y remains the largest contribution of data in the set, all age calculations are limited to those regions. If you read Adamov’s paper that the process originally was developed for, you will learn why.

    BY700 will be most useful for locating new intermediate structures until that time.
    I meant to rephrase my original question because I know that Yfull adjusts the amount of combBED SNPs counted based on the coverage. I meant to say will Big Y-700 kits have more SNPs listed on Yfull than Big Y-500 kits?

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    The BY700 kits just look like Y Elite or WGS tests now. So yes there will be more SNPs, but they don’t impact age calculations since they are outside of the combBED.

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    Quote Originally Posted by JamesKane View Post
    The BY700 kits just look like Y Elite or WGS tests now. So yes there will be more SNPs, but they don’t impact age calculations since they are outside of the combBED.
    Yes, I have noticed that our one Y-Elite, YFull does not use for age calculations the persons new Novel Variants, but why does the "Y-DNA Data Warehouse" on their statistics page have the old Big-Y at 131.6 years per SNP and the new Big-Y at 80.2 years per SNP? What am I missing? Is YFull's age estimation never going to change with these additional SNP's?

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    Quote Originally Posted by JamesKane View Post
    The BY700 kits just look like Y Elite or WGS tests now. So yes there will be more SNPs, but they don’t impact age calculations since they are outside of the combBED.
    Thanks for the reply! So all of the additional coverage is outside the combBED areas? If someone were to upgrade from Big Y-500 to Big Y-700 no additional combBED SNPs would be discovered?

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    Quote Originally Posted by Jeffrey View Post
    Yes, I have noticed that our one Y-Elite, YFull does not use for age calculations the persons new Novel Variants, but why does the "Y-DNA Data Warehouse" on their statistics page have the old Big-Y at 131.6 years per SNP and the new Big-Y at 80.2 years per SNP? What am I missing? Is YFull's age estimation never going to change with these additional SNP's?
    I ignore the combBED in the Y-DNA Warehouse calculations. The estimated age formula uses the reciprocal of the mean callable loci statistic times 8.2e-10 per year per bp as a mutation constant. I expect that mutation constant doesn't hold across the regions outside combBED, but it's close enough for that chart. We need further studies on the regions outside Poznik's call mask to establish a better number.

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    Quote Originally Posted by mwauthy View Post
    Thanks for the reply! So all of the additional coverage is outside the combBED areas? If someone were to upgrade from Big Y-500 to Big Y-700 no additional combBED SNPs would be discovered?
    Since the average Big Y 500 had only 7.7 million of the 8.4 million bases GRCh38 version of combBED, there is a small chance some samples would pick up a position that wasn't covered. It would be much more cost effective to test for missing SNPs individually in these cases.

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    How does read length & insert length look like on BigY 700? I'm assuming FTDNA is doing the same as before, stripping off all off-target reads even if other end mapped to Y.

    I've already done BigY & Dante WGS, so I don't think I can gain anything in terms of SNP's, but I've played with re-assembling the Y chromosome to find any structural variation in my branch due to having two sequences with different read-length & technology. The upgrade seems like afforable way to expand that. But if the insert length is similar, and it only contains bits mapped to current Y reference, I guess it's not going to help whole lot.

    Other thing I'm wondering is if the upgrade can be bought for another person, as it doesn't seem to clearly specify that.

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    Quote Originally Posted by Donwulff View Post
    [SNIP]... Other thing I'm wondering is if the upgrade can be bought for another person, as it doesn't seem to clearly specify that.
    The upgrade is only available to upgrade the old Big Y-500 to the new Big Y-700. They actually have to do the new test so the sale on the upgrade price is probably at or near the cost to complete the test for FTDNA.

    A person cannot use this upgrade to be used for someone else.
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