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Thread: FGC5496 (L21>DF13>FGC5496) and Subclades

  1. #1
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    FGC5496 (L21>DF13>FGC5496) and Subclades

    This new thread is for L21>DF13>FGC5496 subclade information and discussion going forward. I initially announced its discovery HERE.
    148326, FGC-0FW1R, YSID6 & YF3272 R-DF13>FGC5494>*7448>*5496>*5521>*5511>*5539>*5538>* 5508>*5524
     
    Watterson USA GD1/67 & GD3/111, *5508+. GD1ís fatherís sister-23andme pred. 3rd Cous w/ 0.91% DNA shared-3 seg. Largest on Chr1 w/non-Euro admix affirms my NPE paternal Watterson line via aDNA & YDNA. A 2nd pred. 4th cous has same DKA b. 1840's Georgia and MDKA d 1703 IOM. 3rd Cousin FtDNA FF is from the Watterson Ala. *5538+ b. IOM w/ GD6/67 & GD8/111 -SGD3. FGC5539+ a Scot-Ross GD13/111 -SGD8

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    Congratulations on the successful result. Has anyone else tested yet?

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    I'm awaiting a test kit from YSEQ.

    Keith

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    Having tested positive for S7958 in Chromo2, I ordered the test two weeks ago from YSEQ. I am hopeful that I, like Mark, will finally lose my DF13* status after testing for every other Y-SNP in the book (also have FTDNA's BigY on order).

    Jim

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    As known, I have two novel SNPs found in a Public dataset PGP50 sample. These were FGC5495 & FGC5496. The 5495 SNP failed on my Sanger Test due to an X-Cross over but the later SNP 5496 was went Gold as it validated as a clean and positive Sanger test.

    Jim Wilson responded to my personal email I sent asking him about my two new SNPs. He replied that "the SNP you call FGC5495 we call S7958 and does indeed define a new clade in DF13, for which we have 12 members at the minute, including non-British Isles representation! FGC5496 did not get a good design score for the chip and so was not put forward for manufacture. ... For certain S530 samples do not carry S7958 and S7958 men do not carry S530. The other ones you list are a bit rare and we'd actually have to pull out specific samples to test them. Should be able to help show that S7958 men don't carry the other markers that are on the chip.

    Feel free to share this information. None of your private SNPs are on our chip, which is no surprise given that your data were not available at the time it was designed.

    Thanks again for sharing your markers.

    Best wishes
    Jim"


    So I thank Jim Wilson for the info. Of 12 documented positive S7958 Chromo2 guys, two have checked their Chrom2 SNP list and notified us that they are positive for S7958/FGC5495 and have ordered SNP FGC5496 to help in the understanding of this new SNP's breath and depth.

    Chromo2 kit 289737 KeithW , positive result for S7958 SNP. I calculated the TRMCA for 111 markers and there is at least 2,300 ybp TMRCA.

    GD / GD-IAMMCM = 46 / 40
    Mean Generations___StdDevInGen___YBP___+OR-YBP___Max-YBP
    76.6___28.4___2,296.7___53.0___3,149.6

    The second guy, JimW kit 65932 has a patrilineal line from Franconia with about a 1,800 ybp TMRCA.

    GD / GD-IAMMCM = 31 / 29 and a

    Mean Generations___StdDevInGen___YBP___+OR-YBP___Max-YBP

    58.1___ 24.8___ 1,742.3___ 742.9___ 2,485.2

    With my 69 new down stream SNPs, with only two positive, one no-read/no-call and 66 negative from PGP50, this appears to be an old subclade and Keith and Jim tests will help define the new clades boarders.

    Thanks guys! Awaiting your results.

    MJost
    148326, FGC-0FW1R, YSID6 & YF3272 R-DF13>FGC5494>*7448>*5496>*5521>*5511>*5539>*5538>* 5508>*5524
     
    Watterson USA GD1/67 & GD3/111, *5508+. GD1ís fatherís sister-23andme pred. 3rd Cous w/ 0.91% DNA shared-3 seg. Largest on Chr1 w/non-Euro admix affirms my NPE paternal Watterson line via aDNA & YDNA. A 2nd pred. 4th cous has same DKA b. 1840's Georgia and MDKA d 1703 IOM. 3rd Cousin FtDNA FF is from the Watterson Ala. *5538+ b. IOM w/ GD6/67 & GD8/111 -SGD3. FGC5539+ a Scot-Ross GD13/111 -SGD8

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    Good to see this level of cooperation between all the parties concerned.

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    Mark, to clarify, is it known what the relationship is between FGC5495 and FGC5496; which is downstream of which ?

    Keith

  11. #8
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    Interesting Mark thanks for sharing.
    I think FGC5495 and FGC5496 are currently found together, but maybe more testing will resolve them to separate levels in the tree.

    12 positives makes this sound a hefty branch. Franconia is interesting as well.....but remember we also have other central/easterly european members of DF13, so we're not all painted-bodied irish sea types ;-)

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    Should someone who tests postive for S7958+ on the chromo 2 test for FGC5495?

    I just received my results back and tested positive for S7958. My ancestor was from Dieppe. Kit 198135

  13. #10
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    Quote Originally Posted by Brunetmj View Post
    Should someone who tests postive for S7958+ on the chromo 2 test for FGC5495?

    I just received my results back and tested positive for S7958. My ancestor was from Dieppe. Kit 198135
    Chromo2 did test for S7958 and is FGC5495 and it was Sanger Sequenced but failed due to an X-Crossover, FGC5496 needs tested. At 67 markers, you and I are:

    2 HTs Only- GD / GD-IAMMCM = 30 / 24

    IntraClade Coalescence (n-1) Age
    Mean Generations___StdDevInGen___YBP___+OR-YBP___Max-YBP
    68.6___26.9___2,059.1___807.6___2,866.7

    Since PGP50 showed only two of 69 SNPs as being positive, this is an old subclade. So if one is tested negative for all the other DF13 subclades, testing is of interest to define the FGC5496 subclade. I recommend testing as we do not understand the edges of DF13* for this SNP. Expecially with the S7958/FGC5495 being positive between 12 britainsdna guys and me. Please test.

    MJost
    Last edited by MJost; 01-07-2014 at 08:05 PM.
    148326, FGC-0FW1R, YSID6 & YF3272 R-DF13>FGC5494>*7448>*5496>*5521>*5511>*5539>*5538>* 5508>*5524
     
    Watterson USA GD1/67 & GD3/111, *5508+. GD1ís fatherís sister-23andme pred. 3rd Cous w/ 0.91% DNA shared-3 seg. Largest on Chr1 w/non-Euro admix affirms my NPE paternal Watterson line via aDNA & YDNA. A 2nd pred. 4th cous has same DKA b. 1840's Georgia and MDKA d 1703 IOM. 3rd Cousin FtDNA FF is from the Watterson Ala. *5538+ b. IOM w/ GD6/67 & GD8/111 -SGD3. FGC5539+ a Scot-Ross GD13/111 -SGD8

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