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Thread: Best all around raw data file at the moment, with the lowest no-calls?

  1. #1
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    Best all around raw data file at the moment, with the lowest no-calls?

    I am planning to retest my grandmother this black friday, since I discovered that her 23andme V3 file contains more than 7000 no-calls. But I am unsure which company provides the best raw data file these days? It would also help if it is by swab and not spit...


    Detailed overview of no-calls in my family's autosomal files (not including X etc files for those companies that provide separate files):
     

    23andme V2:
    1- 2585
    2- 4386
    3- 3640

    23andme V3:
    1- 7055
    2- 2115

    FTDNA:
    1-6001
    2-10435
    3-12819
    4-10203
    5-8044
    6-5762 (gene by gene)

    LivingDNA:
    1-1896




    Any good tips?
    Last edited by evon; 11-28-2019 at 08:47 PM.

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  3. #2
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    In anticipation of Black Friday deals, one month ago I asked Davidski what would work best with G25. He suggested Ancestry, FTDNA and MyHeritage.
    I trust he knows better than most and went with MyHeritage for my parents.

    MyHeritage and FTDNA use the cheek swap method.

    https://isogg.org/wiki/Autosomal_DNA...mparison_chart
    Last edited by Dorkymon; 11-28-2019 at 08:25 PM.
    Recent ancestry: 2/4 Central Moldova (Orhei district), 1/4 Southern Moldova (Cahul district), 1/4 Northern Moldova (Briceni district)
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  5. #3
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    A lot of us thought the OmniExpress chip raw data from FTDNA and MyHeritage was the gold standard but now they use the new GSA chip and different SNPs. I think now the Living DNA Sirius chip raw data may be the best as they tried to overlap the SNPs on OmniExpress and GSA. Also it is a swab sample. AncestryDNA may make more sense though as it's great to get in their database but it's spit in the vial not swab.

    I'll post my recent results from Living DNA. The table compares my FTDNA OmniExpress raw data upload vs. native swab tests on LDNA's new Sirius chip vs. LDNA's older Orion which is a GSA chip. All are using recent reference panels from this year.

    The FTDNA upload and native LDNA Sirius chip results are quite similar and quite good. If 10% Ireland were moved to South Wales it would line up well with known ancestry. Even so, I'm pleased with those two results on a fairly small group of islands. The comparison with the LDNA Orion/GSA chip isn't as good but not terrible. So Sirius may be the best of both worlds now as far as raw data goes.

    All three miss out on about 4% German/Dutch but that 2.2% Scandinavian in the FTDNA results might be a proxy. Of course that's due to their algorithm and reference panel not a problem with the raw data. My Sirius results are much like FTDNA OmniExpress so there's good SNP overlap. Less so with GSA but probably acceptable.

    Chip ................................ FTDNA ........ Sirius ..... Orion

    Britain&Ireland ................... 97.8 ......... 100.0 ..... 100.0

    Northwest Scotland ............. 14.8 .......... 13.8 ....... 12.5

    Aberdeenshire ...................... 6.9 ............ 7.0 ........ 3.7

    SW Scotland&N. Ireland ..........1.6 ............ 2.7 .............

    Ireland ............................... 28.4 .......... 28.4 ....... 31.1

    Cumbria ............................... 1.9 ............ 1.9 ........ 3.8

    Northumbria ............................................ 1.2 .............

    Northwest England ................. 1.6 ...............................

    North Yorkshire ........................................ 1.8 .............

    South Yorkshire .................... 12.2 .......... 10.1 ........ 6.9

    North Wales .................................................. .......... 1.9

    South Wales ........................... 8.4 ........... 8.7 ......... 4.8

    Cornwall .................................................. ............... 3.8

    South Central England ............ 20.6 ......... 23.0 ....... 23.9

    Southeast England ................... 1.3 ........... 1.3 ........ 7.4

    Scandinavia ............................ 2.2 ...............................
    Last edited by Robert1; 11-28-2019 at 08:42 PM.
     
    Estimated ancestry after reviewing Ancestry.com, 23&Me, FTDNA My Origins, Living DNA and known family history:
    33% English, 27% Scottish, 18% Welsh, 18% Irish, 4% German/Netherlands

    Y-DNA leads to Isle of Skye, Scottish Highlands: R1b>M343>L278>L754>L389>P297>M269>L23>L51>L151/L11>P312>Z290>L21/M529>DF13>L513/DF1>S5668>A7>Z21253> S7834 > S7828 > BY11203 > BY11186 (about 320-550 years old)

    MTDNA leads to Glamorgan, South Wales: K1a4a1f

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    Even my 23andMe V5 contains tons of no-calls. My Ancestry file has none of those, so I would say go with Ancestry.

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    Quote Originally Posted by Dorkymon View Post
    In anticipation of Black Friday deals, one month ago I asked Davidski what would work best with G25. He suggested Ancestry, FTDNA and MyHeritage.
    I trust he knows better than most and went with MyHeritage for my parents.

    MyHeritage and FTDNA use the cheek swap method.

    https://isogg.org/wiki/Autosomal_DNA...mparison_chart
    How many no-calls does your myheritage file have?

  10. #6
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    Quote Originally Posted by JoeyP37 View Post
    Even my 23andMe V5 contains tons of no-calls. My Ancestry file has none of those, so I would say go with Ancestry.
    I don't believe that ancesty has no no-calls, that is statistically improbable.

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    IIRC Dante labs currently has 30x on sale for under 200 dollars. I wouldn't miss that if you can afford it https://us.dantelabs.com/

    Premium Whole Genome Sequencing (30X)
    $189.00 USD $899.00 USD saving $710.00 USD

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    Quote Originally Posted by sktibo View Post
    IIRC Dante labs currently has 30x on sale for under 200 dollars. I wouldn't miss that if you can afford it https://us.dantelabs.com/

    Premium Whole Genome Sequencing (30X)
    $189.00 USD $899.00 USD saving $710.00 USD
    Already ordered one for me, but I don't want to order such a test for my grandmother, a regular DNA test works just fine.

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    Quote Originally Posted by evon View Post
    Already ordered one for me, but I don't want to order such a test for my grandmother, a regular DNA test works just fine.
    That's awesome.
    I should look into no calls, and consider re-prioritizing my own raw data from the sounds of it. I've also been using 23andme v3 due to the larger number of SNPs. Any chance you'd teach me a bit about this? How can I find my no-calls?
    This may not be helpful to you but it appears that Living DNA's current chip offers the largest number of SNPs at this point in time.

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  18. #10
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    Quote Originally Posted by evon View Post
    How many no-calls does your myheritage file have?
    No idea, as I'm on 23andme's v4. My parents' results will be ready in about one month.
    Recent ancestry: 2/4 Central Moldova (Orhei district), 1/4 Southern Moldova (Cahul district), 1/4 Northern Moldova (Briceni district)
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