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Thread: A4 subclades and geographic distribution

  1. #1
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    A4 subclades and geographic distribution

    There are 6 new A4 samples from Denmark published in the Raule et al study of longevity. The 6 samples are similar and probably share a common ancestor around 3000 years ago. They do not share any extra mutations with other A4 samples, so they form a new subclade of A4.

    I checked the Li et al study of 2000 Danes, and there were no A4 samples, but there is an A2a sample and C1b and C4a1 samples from Denmark in Li et al.

    Of course no specific information is available on any of these samples. It would be interesting to know if they represent recent or ancient migrations.

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    Quote Originally Posted by GailT View Post
    I checked the Li et al study of 2000 Danes, and there were no A4 samples, but there is an A2a sample and C1b and C4a1 samples from Denmark in Li et al.
    The A2a one is identical or almost identical to two Greenland Inuit ones from Gilbert et al. Science 320 (5884), 1787-1789 (2008). That's interesting to me but the C1b belongs with Chilean/Penuenche sequences which is somewhat confusing.

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    My brother's Chinese wife's FMS results are in, she is A4-A200G. She only has 2 matches, both at the HVR1 level so I am guessing she is fairly unique. Both matches have only tested HVR1, one appears to be Japanese and the other uncertain, however since they are HVR1 matches the connection could be tens of thousands years old and not relevant. She is in the two applicable mtDNA haplogroup projects now, and I think she is planning on submitting to GenBank at some point. There are two other A4-A200G in the A project, presumably too distant to show up as matches.

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    My sister-in-law is in GenBank now, she is KX459697. She is from a rural village near Shiyan. Apparently Wuhan, which is in Hubei province with Shiyan, is a pocket where Haplogroup A is found in higher frequency http://www.cell.com/ajhg/fulltext/S0002-9297(07)60267-5

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    My brother's Chinese wife's FMS results are in, she is A4-A200G. She only has 2 matches, both at the HVR1 level she is fairly unique.

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    Hi everyone, i just got my results and i also belong to the A4-A200G haplogroup. As far as i know my grandmother and her family is from the Moscow area. I have no matches :-(

  7. The Following User Says Thank You to Mariamij For This Useful Post:

     Táltos (01-29-2017)

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    Quote Originally Posted by Mariamij View Post
    Hi everyone, i just got my results and i also belong to the A4-A200G haplogroup. As far as i know my grandmother and her family is from the Moscow area. I have no matches :-(
    Welcome to Anthrogenica!

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    There have been major revisions to the Phylotree for haplogroup A (link).

    I think A4-A200G is now defined to be A13 and A14. You can check Ian Logan's page for these two subclades (link) to see if you have any close matches in GenBank.

    A200G is also one of the defining mutations for A2af1b1a, so if you are not in A13 or A14, you can check to see if you are in A2af1b1a.

  10. The Following User Says Thank You to GailT For This Useful Post:

     Táltos (01-30-2017)

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    A200G is HVR2 mutation, the old A4 haplogrpup classification is somewhat confusing. I noticed NA18146 Chinese in Denver was grouped as A4c then A13'14 now A(T152C T16362C A200G).

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    Hello, After the FTDNA Build 17 update, my mother's Haplogroup is now A2ao. Her kit is 447313 and we are participating in the FTDNA A2 Project. She has deep roots in the Northern Mexican State of Nuevo Leon. We still have not had any matches and I am wondering if anyone has any information on Haplogroup A2ao? Thank you.

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