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Thread: What is the origin of mtDA U6?

  1. #1
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    What is the origin of mtDA U6?

    So far so good.

    We have a 35kya Paleolithic Romanian woman with basal U6*.

    A 25kya Dzudzuana man with U6 in Georgia.

    And finally plenty of 15kya U6 in Taforalt. Iberomaurusian culture being 23kya to 25kya.

    MtDNA U6 and mtdna U5 are sisters. They were born from the same West Eurasian autosomal mother somewhere around 45-40kya maximum.

    U6 is *estimated* having entered North Africa 25 to 30kya.

    So very little time and space actually separate mtdna U6* in Paleolithic Romania and the direct ancestors of Iberomaurusians.

    So the theory of Iberomaurusians being Cromagnon isn't far fetched at the end of the day because Mesolithic Europeans and Mesolithic Iberomaurusians were definitely closely related via mtDNA and morphological appearance.

    In fact the theory of Iberomaurusians having inherited Eurasian DNA from Mesolithic Europe/Balkan or Mesolithic Anatolia is still circulating around the web.

    The theory of their Eurasian DNA is a Dzudzunua-like source spreading from Paleolithic West Asia has become widespread due to the recent papers (2017).
    Last edited by Bealfire; 02-05-2020 at 09:39 PM.

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    Yes, I think mtDNA U6 has been found in a couple of UP Romanian fossils (~35 kyr). However, there's no evidence they're directly related to the Dzudzuana people or Iberomaurisians (we don't have genomic DNA to test that). Haplogroup R1b was also found in a 14000 year old man from Northern Italy (Villabruna 1) and a substantial amount of present-day Italian men are R1b, but their subclades aren't directly related to Villabruna 1 and they arrived much later to the region. Curiously, virtually all U6 in Europe (its frequency is highest in Iberia) appears to be descended from NW African clades.

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    It is very useful to have a look at the phylogenetic tree of U6 haplotypes in order to judge their dispersal pattern:
    Additional file 2: U6 phylogenetic tree based on 230 complete sequences

    It is part of this fairly recent paper:
    The history of the North African mitochondrial DNA haplogroup U6 gene flow into the African, Eurasian and American continents, 2014
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062890/

    This paper on both U6 and M1 is also fairly recent and informative:
    Divorcing the Late Upper Palaeolithic demographic histories of mtDNA haplogroups M1 and U6 in Africa, 2012

    https://bmcevolbiol.biomedcentral.co...71-2148-12-234

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    Quote Originally Posted by Milkyway View Post
    Yes, I think mtDNA U6 has been found in a couple of UP Romanian fossils (~35 kyr). However, there's no evidence they're directly related to the Dzudzuana people or Iberomaurisians (we don't have genomic DNA to test that). Haplogroup R1b was also found in a 14000 year old man from Northern Italy (Villabruna 1) and a substantial amount of present-day Italian men are R1b, but their subclades aren't directly related to Villabruna 1 and they arrived much later to the region. Curiously, virtually all U6 in Europe (its frequency is highest in Iberia) appears to be descended from NW African clades.
    IIRC the Hervella paper showed the Muierii sample to be *basal* U6. So there might be a chance they actually are directly related.

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    Quote Originally Posted by epoch View Post
    IIRC the Hervella paper showed the Muierii sample to be *basal* U6. So there might be a chance they actually are directly related.
    I meant from a more global perspective, that is, if Paleolithic populations with U6 lineages are related and/or ancestral to one another. I think this can only be tested with genomic DNA.

  10. #6
    Most likely U6 entered north africa with E1b1b at 25,000 yr and founded the Iberomaurusian industry, because the Iberomaurusians appearance seems to be correlated with the Eurasian back-migration into north africa.
    an intermediate population who lived between Levant and Caucasus is the likely ancestor.
    Last edited by Nebro; 02-06-2020 at 05:55 PM.

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    Quote Originally Posted by Nebro View Post
    Most likely U6 entered north africa with E1b1b at 25,000 yr and founded the Iberomaurusian industry, because the Iberomaurusians appearance seems to be correlated with the Eurasian back-migration into north africa.
    an intermediate population who lived between Levant and Caucasus is the likely ancestor.
    E1b1b (E-M215) originated in the Horn of Africa not in the Levant unless you are suggesting that E-M215 men entered North Africa from the south when U6 females entered Africa from the Levant.

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    [Moderator: racist comment deleted]

    There's no real concrete material proof of this. For now all the oldest EM215 are in North Africa and Levant. Oldest EM215* lineage found in North Africa too.
    Last edited by Moderator; 02-06-2020 at 09:38 PM. Reason: Racism not tolerated

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  16. #9
    Quote Originally Posted by drobbah View Post
    E1b1b (E-M215) originated in the Horn of Africa not in the Levant unless you are suggesting that E-M215 men entered North Africa from the south when U6 females entered Africa from the Levant.
    Horn of africa origin is no longer supported by ancient dna ..the Diversity stuff is outdated.
    It seems ancient dna points to multiple back migrations from Near east carrying E1b1b into africa into northern and east africa from the levant or arabia.
    The E1b1b in horn africa is assosiated with Eurasian ancestry from the levant.
    Seems to have replaced the haplogroup B and A..preserved by Hadza-like groups.

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    E-M35 originated in North Africa and all the relevant aDNA should make that pretty obvious by now.

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