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Thread: SARS-CoV-2 respiratory failure: risk SNPs, Bloodtype A is a risk, O is protective

  1. #111
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    Found: genes that sway the course of the coronavirus
    By Jocelyn Kaise
    in Science

    Overview of studies previously posted in this thread.
    YFull: YF14620 (Dante Labs 2018)

  2. The Following User Says Thank You to pmokeefe For This Useful Post:

     Mis (10-14-2020)

  3. #112
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    Reduced prevalence of SARS-CoV-2 infection in ABO blood group

    Reduced prevalence of SARS-CoV-2 infection in ABO blood group
    Mike Bogetofte Barnkob, Anton Pottegård, Henrik Støvring, Thure Mors Haunstrup, Keld Homburg, Rune Larsen, Morten Bagge Hansen, Kjell Titlestad, Bitten Aagaard, Bjarne Kuno Møller, Torben Barington

    Key Points
    Blood group O is associated with a decreased risk for contracting SARS-CoV-2 infection.

    Abstract
    Identification of risk factors for contracting and developing serious illness following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is of paramount interest. Here, we performed a retrospective cohort analysis of all Danish individuals tested for SARS-CoV-2 between 27 February 2020 and 30 July 2020, with a known ABO and RhD blood group, to determine the influence of common blood groups on virus susceptibility. Distribution of blood groups was compared with data from nontested individuals. Participants (29% of whom were male) included 473 654 individuals tested for SARS-CoV-2 using real-time polymerase chain reaction (7422 positive and 466 232 negative) and 2 204 742 nontested individuals, accounting for ∼38% of the total Danish population. Hospitalization and death from COVID-19, age, cardiovascular comorbidities, and job status were also collected for confirmed infected cases. ABO blood groups varied significantly between patients and the reference group, with only 38.41% (95% confidence interval [CI], 37.30-39.50) of the patients belonging to blood group O compared with 41.70% (95% CI, 41.60-41.80) in the controls, corresponding to a relative risk of 0.87 (95% CI, 0.83-0.91) for acquiring COVID-19. This study identifies ABO blood group as a risk factor for SARS-CoV-2 infection but not for hospitalization or death from COVID-19.
    Last edited by pmokeefe; 10-15-2020 at 06:55 PM.
    YFull: YF14620 (Dante Labs 2018)

  4. #113
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    ABO blood group with indices of disease severity and dysfunction in COVID-19

    The association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19
    Ryan L. Hoiland, Nicholas A. Fergusson, Anish R. Mitra, Donald E. G. Griesdale, Dana V. Devine, Sophie Stukas, Jennifer Cooper, Sonny Thiara, Denise Foster, Luke Y. C. Chen, Agnes Y. Y. Lee, Edward M. Conway, Cheryl L. Wellington, Mypinder S. Sekhon
    Key Points
    COVID-19 patients with blood group A or AB are at increased risk for requiring mechanical ventilation vs those with blood group O or B.
    COVID-19 patients with blood group A or AB appear to exhibit a greater disease severity than patients with blood group O or B.
    Abstract
    Studies on severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) suggest a protective effect of anti-A antibodies against viral cell entry that may hold relevance for SARS-CoV-2 infection. Therefore, we aimed to determine whether ABO blood groups are associated with different severities of COVID-19. We conducted a multicenter retrospective analysis and nested prospective observational substudy of critically ill patients with COVID-19. We collected data pertaining to age, sex, comorbidities, dates of symptom onset, hospital admission, intensive care unit (ICU) admission, mechanical ventilation, continuous renal replacement therapy (CRRT), standard laboratory parameters, and serum inflammatory cytokines. National (N = 398 671; P = .38) and provincial (n = 62 246; P = .60) ABO blood group distributions did not differ from our cohort (n = 95). A higher proportion of COVID-19 patients with blood group A or AB required mechanical ventilation (P = .02) and CRRT (P = .004) and had a longer ICU stay (P = .03) compared with patients with blood group O or B. Blood group A or AB also had an increased probability of requiring mechanical ventilation and CRRT after adjusting for age, sex, and presence of ≥1 comorbidity. Inflammatory cytokines did not differ between patients with blood group A or AB (n = 11) vs O or B (n = 14; P > .10 for all cytokines). Collectively, our data indicate that critically ill COVID-19 patients with blood group A or AB are at increased risk for requiring mechanical ventilation, CRRT, and prolonged ICU admission compared with patients with blood group O or B. Further work is needed to understand the underlying mechanisms.
    YFull: YF14620 (Dante Labs 2018)

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