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Thread: About that human Y Chromosome

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    About that human Y Chromosome

    GENES ON THE Y CHROMOSOME
    Compared to the other human chromosomes, the Y chromosome has a limited number of genes. The Y gene poverty may have been the result of the known the tendency of Y chromosome's genes to degenerate during evolution, being nowadays the relic of an ancient common ancestry with the X chromosome (Graves [10]). Both mammalian X and Y chromosomes evolved from ancestral autosomes. The most ancestral gene functions were retained on the nascent X chromosome but deteriorated on NRY portion of the emerging Y (Bull [11]) giving females with two copies but males with only one copy of many genes. The gene dosage problem has been solved through inactivation of one X chromosome in females.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC79676/

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    This has been known for a while -- in fact, the paper is almost 20 years old.

    Since the paper also mentions X inactivation, it's important to note that people sometimes misunderstand how this works. They may believe that the same X is inactivated throughout the entire body, but in humans this is not the case.

    Very early in embryonic development -- when there are only a very small number of cells -- X inactivation occurs within each of them. Their respective daughter cells retain the same X inactivation, thus "Because X-inactivation is random, in normal females the X chromosome inherited from the mother is active in some cells, and the X chromosome inherited from the father is active in other cells."

    https://ghr.nlm.nih.gov/chromosome/X...%20body%20cell.
    Last edited by geebee; 06-23-2020 at 06:41 PM.
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