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Thread: Europe's Hidden Matrilineal Dynasty - House of Garsenda

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    Europe's Hidden Matrilineal Dynasty - House of Garsenda

    https://en.wikipedia.org/wiki/Garsen...of_Forcalquier



    The mt-haplogroup is H, but it's not clear which exact subclade.
    Last edited by Pribislav; 09-28-2020 at 09:46 PM.

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    After further research I think it's safe to say that mt-haplogroup of Garsenda and her matrilineal descendants is H1af2 (C4137T). Three samples in the tree are from the remains of murdered family members of Nikolai II Romanov, the last Russian Emperor: his wife Empress Alexandra Feodorovna of Hesse (1872-1918), and two of their five children, Grand Duchess Maria (1899-1918) and Prince Alexei (1904-1918). The results were published in the paper Genomic identification in the historical case of the Nicholas II royal family by Rogaev et al. 2008:

    FJ656214.1 (Empress Alexandra)

    FJ656216.1 (Prince Alexei)

    FJ656217.1 (Grand Duchess Maria)

    From the paper:

    Employing 3 different amplification approaches (Material and Methods), we successfully determined genomic cmtDNA sequences for N146 (Alexei) and N147 (Maria), and the N7 (Alexandra) specimen. Next, we determined cmtDNA sequences for living relatives from 2 different branches of the maternal lineage of Queen Victoria who is grandmother of Empress Alexandra (Material and Methods, Fig. 2, and Fig. S2). The resulting alignment showed a perfect match between the 16,571-bp cmtDNA sequences of N146, N147 and N7 samples and sequences of the great2-granddaughter and great4-granddaughter of Queen Victoria (Table 1). We designated this mitotype as ‘‘Queen Victoria’’ type.

    In large population databases for HVR1 sequences, which include Russian, East and West European populations (Table S1), we found that this ‘‘Queen Victoria’’ mtDNA type (identical in putative remains of Empress Alexandra, her children and Queen Victoria’s living descendants) is very rare in human populations. In a collection of 70,000 individuals with available HVR1 data we found only 1 individual with an identical profile (Table S1). We requested and obtained DNA from this individual (M.T.), who is of Canadian origin, but with presumable ancestral origins from Germany, for a more comprehensive analysis. Additional analysis of D-loop showed mismatches for position 524.1 and 524.2 (no insertion in the tested individual, and 524.1A and 524.2C in ‘‘Queen Victoria’’ type mt DNA). The entire mtDNA sequences retrieved from the putative remains of Empress Alexandra and her children show no match to any individual from the population database for human cmtDNA sequences (Table S1). Thus, the mtDNA profiles found in skeletal remains N146; N147; and N7, N3, N5, and N6 (‘‘Queen Victoria’’ mtDNA type) are unique (not found in available databases).

    Wikipedia article is now updated with mtDNA information:

    https://en.wikipedia.org/wiki/Garsen...al_DNA_results
    Last edited by Pribislav; 09-28-2020 at 09:54 PM.

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    Last edited by Pribislav; 09-28-2020 at 11:24 PM.

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