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Thread: U2 mutations connection to N9a3 N9a8

  1. #1
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    Post U2 mutations connection to N9a3 N9a8

    Hello,
    Any one posses U2 mutation like 'T11368C' connecting to K N9a3 N9a8 M7a1a4a ? I got that mutation according to Ian Hogan which is not seen among U2a1a mtdna group.
    Last edited by tipirneni; 04-08-2021 at 07:40 PM.
    Y: H1a1a4b3b1a8 Yfull id-> YF83218
    Medals->Hidden Content
    mtDNA:U2a1a2
    G25 Ancients Dist 1.0 IRN_Shahr_I_Sokhta_BA2 88.4 MAR_Taforalt 2.6NPL_Mebrak 5
    VK2020_SWE_Gotland_VA 4 Hidden Content

    Lactose Persistence rs3213871 rs4988243 rs4988183 rs3769005 rs2236783
    found -> DA125, Kangju

  2. #2
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    Quote Originally Posted by tipirneni View Post
    Hello,
    Any one posses U2 mutation like 'T11368C' connecting to N9a3 N9a8 M7a1a4a ? I got that mutation according to Ian Hogan which is not seen among U2a1a mtdna group.
    Most have such extra mutations. mtDNA have very few mutations and this mutation can be thousands of year old. Do you think it is a new mutation?

  3. The Following User Says Thank You to Jatt1 For This Useful Post:

     tipirneni (04-08-2021)

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    Quote Originally Posted by Jatt1 View Post
    Most have such extra mutations. mtDNA have very few mutations and this mutation can be thousands of year old. Do you think it is a new mutation?
    I checked on web K shows up as backmutation at that place. 16311 is supposed to be high heteroplasty so things change quickly. Looks like Otzi had it as a extra mutation. This is present widely in N9 and M7 population of Steppe and Far east. Since I have both these admixtures Otzi in copper age and then Steppe/far east coming in multiple waves it is possible it could have come at any time. But U2a1a mtdna having this mutation apparently didn't occur before.

    ....... K A3480G A10550G T11299C T14798C T16224C T16311C!

    A recent study by Rollo et al. (2006) attempted to determine, at a fine level of molecular resolution, the phylogenetic position of the Iceman’s mtDNA by genotyping a set
    of conservative coding region markers. The re-examination confirmed the control region signature mutations
    T16224C/T16311C characteristic of haplogroup K reported earlier in the study by Handt et al. (1994).

    https://www.csueastbay.edu/museum/fi...solved-loc.pdf
    Y: H1a1a4b3b1a8 Yfull id-> YF83218
    Medals->Hidden Content
    mtDNA:U2a1a2
    G25 Ancients Dist 1.0 IRN_Shahr_I_Sokhta_BA2 88.4 MAR_Taforalt 2.6NPL_Mebrak 5
    VK2020_SWE_Gotland_VA 4 Hidden Content

    Lactose Persistence rs3213871 rs4988243 rs4988183 rs3769005 rs2236783
    found -> DA125, Kangju

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    From https://www.nature.com/articles/ncom...df?origin=ppub
    Shows several deep clades > 50k TMRCA such as F1, N9, B4 have this T16311C mutation. Probably prior to peopling of farmers these people existed all over eastern asia

    Table 2 | Estimated time to the most recent common
    ancestor (TMRCA) of the haplogroups and their haplotype
    diversity in Cambodians.

    Haplogroup n TMRCA (years)* Haplotype diversityw
    425,000 years ago:
    M68z 14 82,782±22,020y /
    F1 192 76,158±28,610 0.9162
    M69z 13 68,137±20,797y 0.4545
    B4 59 60,772±26,019 0.7434
    F1a 188 60,676±24,108 0.9129
    M78z 7 55,188±13,086y /
    R9 26 51,955±18,766 0.8615
    R9b 25 50,698±19,345 0.8533
    F1a1a 138 47,977±21,121 0.8643
    B4c2 52 44,900±23,405 0.6757
    M74 52 39,420±19,710 0.5083
    F1a1a1 69 36,738±15,364 0.7451
    N7z 13 36,388±11,281 0.7949
    M51 21 35,207±13,866 0.819
    N9a 11 34,870±14,463 0.8364
    B5a 288 34,220±18,389 0.8364
    B5 296 34,140±1,7899 0.8456
    M7b 21 33,354±15,276 0.7048
    M3dz 14 28,908±12,248y /
    M59z 2 27,594±10,430y /
    B5a1a 96 26,232±17,043 0.7342
    B5a1 287 26,149±13,682 0.8361
    M21 28 25,736±18,007 0.5767
    M20 14 25,016±15,021 0.7143
    Y: H1a1a4b3b1a8 Yfull id-> YF83218
    Medals->Hidden Content
    mtDNA:U2a1a2
    G25 Ancients Dist 1.0 IRN_Shahr_I_Sokhta_BA2 88.4 MAR_Taforalt 2.6NPL_Mebrak 5
    VK2020_SWE_Gotland_VA 4 Hidden Content

    Lactose Persistence rs3213871 rs4988243 rs4988183 rs3769005 rs2236783
    found -> DA125, Kangju

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    https://dash.harvard.edu/bitstream/h...pdf?sequence=1

    Mitochondrial DNA analysis of Eneolithic Trypillians from Ukraine reveals
    neolithic farming genetic roots

    The Cucuteni-Trypillia culture complex dominated the cultural landscape of the Carpathian
    foothills in eastern Romania, Moldova and the territory of modern-day Ukraine west of the
    Dnieper River during the Eneolithic (Copper Age) period in eastern Europe, ca. 5,400–2,700
    BCE. It is known as the Cucuteni culture in its western ranges, while in its eastern part it is
    known as the Trypillian culture (TC) after the village of Trypillia in what is now central
    Ukraine where it was first identified by Vikentij Khvoika in the late 19th century


    Specimen ID, radiocarbon age (2σ) Mitochondrial haplogroup SNPs

    V1.1.1, 3,700–3,500cal BCE U8b1a2 C7028T, A12308G,T16172C, C16259T, C16266T, T16311C


    The sample V1.1.1 found in Trypillian culture is U8b1a2 considered upper paleolithic European mtDNA also carries this T16311C mutation
    Y: H1a1a4b3b1a8 Yfull id-> YF83218
    Medals->Hidden Content
    mtDNA:U2a1a2
    G25 Ancients Dist 1.0 IRN_Shahr_I_Sokhta_BA2 88.4 MAR_Taforalt 2.6NPL_Mebrak 5
    VK2020_SWE_Gotland_VA 4 Hidden Content

    Lactose Persistence rs3213871 rs4988243 rs4988183 rs3769005 rs2236783
    found -> DA125, Kangju

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    Quote Originally Posted by tipirneni View Post
    Hello,
    Any one posses U2 mutation like 'T11368C' connecting to K N9a3 N9a8 M7a1a4a ? I got that mutation according to Ian Hogan which is not seen among U2a1a mtdna group.
    Ian Logan has a list of U2a samples at this link, and there is a sample with T11368C but it appears to be a partial sequence, perhaps from 23andMe or some other partial test, so it is not very helpful. But you can compare your full sequence results to the other U2a1a samples on that page to see if you match other mutations with those samples.

    Marker 16311 is highly variable so I would ignore it.

  8. #7
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    Quote Originally Posted by GailT View Post
    Ian Logan has a list of U2a samples at this link, and there is a sample with T11368C but it appears to be a partial sequence, perhaps from 23andMe or some other partial test, so it is not very helpful. But you can compare your full sequence results to the other U2a1a samples on that page to see if you match other mutations with those samples.

    Marker 16311 is highly variable so I would ignore it.
    .. ('Shireesh Agrawal'-huD4860C) U2a1 73G 200G 263G 750G 1438G 1811G 2706G 4769G 7028T 11368C 11467G 11719A 12372A 14766T 16051G 16093A 16206G 16311C

    seems to lack only few mutations I have. Also looks like the Agrawals and Jains banias are from the same stock of people as me, But they mixed with later MLBA waves whereas we are more unmixed Jain/Buddhist heritage groups.
    Y: H1a1a4b3b1a8 Yfull id-> YF83218
    Medals->Hidden Content
    mtDNA:U2a1a2
    G25 Ancients Dist 1.0 IRN_Shahr_I_Sokhta_BA2 88.4 MAR_Taforalt 2.6NPL_Mebrak 5
    VK2020_SWE_Gotland_VA 4 Hidden Content

    Lactose Persistence rs3213871 rs4988243 rs4988183 rs3769005 rs2236783
    found -> DA125, Kangju

  9. #8
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    On YFULL, I am placed under U2a1a* https://www.yfull.com/mtree/U2a1a/

    There is a Kashmiri KU178920 person and another from Palanisamy 2006 dataset Uttar Pradesh GQ337552 person sharing the U2a1a* branch. However these two dont have some of the mutations that my kit has
    Last edited by tipirneni; 04-16-2021 at 04:25 AM.
    Y: H1a1a4b3b1a8 Yfull id-> YF83218
    Medals->Hidden Content
    mtDNA:U2a1a2
    G25 Ancients Dist 1.0 IRN_Shahr_I_Sokhta_BA2 88.4 MAR_Taforalt 2.6NPL_Mebrak 5
    VK2020_SWE_Gotland_VA 4 Hidden Content

    Lactose Persistence rs3213871 rs4988243 rs4988183 rs3769005 rs2236783
    found -> DA125, Kangju

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