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Thread: Neanderthal gene protective of COVID19

  1. #1
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    Neanderthal gene protective of COVID19

    https://www.nature.com/articles/s41591-021-01281-1

    A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity

    Sirui Zhou, Guillaume Butler-Laporte, […]J. Brent Richards
    Nature Medicine (2021)Cite this article

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    Abstract
    To identify circulating proteins influencing Coronavirus Disease 2019 (COVID-19) susceptibility and severity, we undertook a two-sample Mendelian randomization (MR) study, rapidly scanning hundreds of circulating proteins while reducing bias due to reverse causation and confounding. In up to 14,134 cases and 1.2 million controls, we found that an s.d. increase in OAS1 levels was associated with reduced COVID-19 death or ventilation (odds ratio (OR) = 0.54, P = 7 × 10−8), hospitalization (OR = 0.61, P = 8 × 10−8) and susceptibility (OR = 0.78, P = 8 × 10−6). Measuring OAS1 levels in 504 individuals, we found that higher plasma OAS1 levels in a non-infectious state were associated with reduced COVID-19 susceptibility and severity. Further analyses suggested that a Neanderthal isoform of OAS1 in individuals of European ancestry affords this protection. Thus, evidence from MR and a case–control study support a protective role for OAS1 in COVID-19 adverse outcomes. Available pharmacological agents that increase OAS1 levels could be prioritized for drug development.
    And the good news is both 23andMe and FT-DNA measured rs10774671
    I had great hopes because I have a lot of Neanderthal in me. I am G/A and it is apparently sufficient to be in the « good » group.
    Avatar: carte G25 Map par/by ph2ter
    K13 : 55.7% North_Dutch + 44.3% Spanish_Andalucia @ 1,7
    K15 : 79.6% Orcadian + 20.4% Sardinian @ 3,27
    Of course one population is French... @ 4,09 and 5,38 for K13 and K15.
    Y-DNA of ancestors include R U-152> R-Z193> BY3642> BY3654, J-M67 (from 23andMe genocousins -12 lines to this ancestor),
    J-CTS1192 (Z387) and E-L117 (from French Heritage DNA Project at FT-DNA)

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    It is therefore necessary to have an ancestral allele (G) for that "the protective effect size was particularly large, such that a 50% decrease in the odds of very severe COVID-19 was observed"

    I am GG (V3 23andMe) but this marker is not test with V5!
    Y haplogroup: R1b: L21 --> DF13 --> BY145002
    The oldest L21 known are I2457 et I2565 from Stonehenge (Beaker Culture, 2400-1900 BC)

    MTDNA: U4c1
    The oldest U4c1 known are "poz224", Yamnaya culture (2882-2698 BC), and 2 Bell-Beaker in Germany (Karsdorf, 2314-2042 BC)

    Paternal MTDNA: K1b2b
    The oldest K1b2 are Eastern European Mesolithic: Kunda Donkalnis5 (Lithuania), 6000 BC and Meso-Ene Lepenski Vir Lepe28 in Serbia, 5900 BC.
    The oldest K1b2b is Alt-3, Corded-Ware Germany (2500 BC)

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    I am GG at rs10774671...What does that mean exactly? I got two copies of the protective allele?

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    Quote Originally Posted by Tolan View Post
    It is therefore necessary to have an ancestral allele (G) for that "the protective effect size was particularly large, such that a 50% decrease in the odds of very severe COVID-19 was observed"

    I am GG (V3 23andMe) but this marker is not test with V5!
    I was also tested with V3 in 2014. Ironically 23andMe is now showing a tool to assess a person’s risk of COVID-19. I was going to suggest they add this in their system, but may bite their nails of having dropped it!

    Edit: also available in my 2016 AncestryDNA test - not sure of new version.
    Last edited by Titane; 03-01-2021 at 10:24 PM.
    Avatar: carte G25 Map par/by ph2ter
    K13 : 55.7% North_Dutch + 44.3% Spanish_Andalucia @ 1,7
    K15 : 79.6% Orcadian + 20.4% Sardinian @ 3,27
    Of course one population is French... @ 4,09 and 5,38 for K13 and K15.
    Y-DNA of ancestors include R U-152> R-Z193> BY3642> BY3654, J-M67 (from 23andMe genocousins -12 lines to this ancestor),
    J-CTS1192 (Z387) and E-L117 (from French Heritage DNA Project at FT-DNA)

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     Arnfried (03-02-2021),  Tolan (03-01-2021)

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    Quote Originally Posted by J Man View Post
    I am GG at rs10774671...What does that mean exactly? I got two copies of the protective allele?
    The effect is with an increase in P46 protein production. The paper does not distinguish between GG and GA.
    Avatar: carte G25 Map par/by ph2ter
    K13 : 55.7% North_Dutch + 44.3% Spanish_Andalucia @ 1,7
    K15 : 79.6% Orcadian + 20.4% Sardinian @ 3,27
    Of course one population is French... @ 4,09 and 5,38 for K13 and K15.
    Y-DNA of ancestors include R U-152> R-Z193> BY3642> BY3654, J-M67 (from 23andMe genocousins -12 lines to this ancestor),
    J-CTS1192 (Z387) and E-L117 (from French Heritage DNA Project at FT-DNA)

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     J Man (03-01-2021)

  10. #6
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    Quote Originally Posted by Titane View Post
    The effect is with an increase in P46 protein production. The paper does not distinguish between GG and GA.
    So G is the protective allele inherited from Neanderthals correct?

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    The allele G (for Europeans) does not necessarily come from Neanderthal!

    It is possible that our lines have always had this ancestral allele, while other Europeans have inherited a new variant ...
    Y haplogroup: R1b: L21 --> DF13 --> BY145002
    The oldest L21 known are I2457 et I2565 from Stonehenge (Beaker Culture, 2400-1900 BC)

    MTDNA: U4c1
    The oldest U4c1 known are "poz224", Yamnaya culture (2882-2698 BC), and 2 Bell-Beaker in Germany (Karsdorf, 2314-2042 BC)

    Paternal MTDNA: K1b2b
    The oldest K1b2 are Eastern European Mesolithic: Kunda Donkalnis5 (Lithuania), 6000 BC and Meso-Ene Lepenski Vir Lepe28 in Serbia, 5900 BC.
    The oldest K1b2b is Alt-3, Corded-Ware Germany (2500 BC)

  12. #8
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    Im AA on rs10774671.. Too bad because I hate wearing masks. F that

  13. #9
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    Actually the ancestral (G) variant is from africans. On snpedia it's very common among yoruba. This is what it says

    Most present-day individuals of European ancestry carry the alternative variant (rs10774671-A). The ancestral variant (rs10774671-G) is the major allele in African populations and became fixed in Neanderthal and Denisovan genomes24,25. However, the ancestral variant, with its increased expression of the p46 isoform, was reintroduced into the European population via gene flow from Neanderthals26
    But I don't think it has to do with neanderthals, because east asians have neanderthals but have a much higher % of A
    Last edited by Bbgum; 03-01-2021 at 08:18 PM.

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    rs10774671 12 113357193 AG

    So i have the COVID-resistant gene?

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