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Thread: Neanderthaler pigmentation inheritance BNC2

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    Neanderthaler pigmentation inheritance BNC2

    @yourgeneheritage there is a part about skin darkness, my father (and I partly) got this result:



    BNC2 M= more dark

    Some quick research learned that this genes are a Neanderthal heritage.

    In Michael Dannemann and Janet Kelso, The Contribution of Neanderthals to Phenotypic Variation in Modern Humans (2017), there is a crucial passage:

    Interestingly, a second, less-frequent (19%) archaic haplotype near BNC2 (chr9: 16,891,561–16,915,874; rs62543578; Table S6) shows strong associations with darker skin pigmentation in individuals with British ancestry in the UK Biobank cohort.
    But I couldn't find this snp among the ftdna file and also no information on snpedia, has anyone some additional information?
    Last edited by Finn; 04-12-2021 at 07:13 PM.

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    strong associations with darker skin pigmentation
    It's one or the other lol

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    Quote Originally Posted by CopperAxe View Post
    It's one or the other lol
    May be it's more complicated, I know that blond hair and blue eyes are most common here, absolutely.

    But to give you an example I discovered this weekend face app. So I could put my grandfather in the time machine. Wonderfull. But this is what a more pigmented Groninger looks like...he could tan very well!



    I guess there are more snp's at stake (some giving dark some light results)....but I also saw that Fitzgerald skintype III is quite common in our area.

    At least: the 'minority' with some darker features has obviously very archaic roots!!
    Last edited by Finn; 04-13-2021 at 03:27 PM.

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    Quote Originally Posted by CopperAxe View Post
    It's one or the other lol
    Still convinced it's one of the other......?

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    Quote Originally Posted by CopperAxe View Post
    It's one or the other lol
    There was a guy who made some Neanderthaler influenced phenotypes, when I compare this with the Danneman (2017) and the foto of my grandfather it's striking (my wife without knowing thougth he was even A, A is 'pure' Neanderthaler and F is least Neanderthaler....). In my opinion he fits B/C. Coincidence? Projecting?



    Last edited by Finn; 04-15-2021 at 05:37 AM.

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    Quote Originally Posted by Finn View Post
    Still convinced it's one of the other......?
    Mate I'm half Kenyan and live in the randstad my definition of dark is probably a bit different than yours.

    But yeah I was kidding around actually (for the most part), I know a couple of people from Friesland who are as Frisian as can be but have darker hair and tan quite fast. So I know they exist! Mythical creatures, the swarthy Frisians.

    With pigmentation there are so many snps and combinations of snps at play here that in my eyes it is hard to link the darker northerner profile directly to this neanderthal gene in particular.

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    Quote Originally Posted by CopperAxe View Post
    Mate I'm half Kenyan and live in the randstad my definition of dark is probably a bit different than yours.

    But yeah I was kidding around actually (for the most part), I know a couple of people from Friesland who are as Frisian as can be but have darker hair and tan quite fast. So I know they exist! Mythical creatures, the swarthy Frisians.

    With pigmentation there are so many snps and combinations of snps at play here that in my eyes it is hard to link the darker northerner profile directly to this neanderthal gene in particular.
    Of course I knew there was some tongue in cheek

    Direct links are absurd I guess there no 'UP survivors' ......hahah

    Nevertheless the archaic look of grandpapa, seen the pictures, is IMO obvious. And Dannenam e.a. (2017) really showed that the influence is there:
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630192/

    The latest publication in this respect from Yair (2021), talks also about this introgression:
    https://academic.oup.com/genetics/ad...yab052/6205711

    So no direct but indirect influence on the phenotype remarkable or not is less and less fare fetched....! So the archaic look of 'the grand old man' isn't that too?
    Last edited by Finn; 04-15-2021 at 09:14 AM.

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    Quote Originally Posted by CopperAxe View Post
    Mate I'm half Kenyan and live in the randstad my definition of dark is probably a bit different than yours.

    But yeah I was kidding around actually (for the most part), I know a couple of people from Friesland who are as Frisian as can be but have darker hair and tan quite fast. So I know they exist! Mythical creatures, the swarthy Frisians.

    With pigmentation there are so many snps and combinations of snps at play here that in my eyes it is hard to link the darker northerner profile directly to this neanderthal gene in particular.

    This scheme from Yair (2021) reveals much:



    Many of those Neanderthal derived snps affect the phenotype. And even more from being a morning or evening person to vulnerability to covid!
    Last edited by Finn; 04-15-2021 at 06:59 AM.

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    I'm curios about what other members thinks about this Neanderthaler derived influence on the phenotype!

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    acc. to an 2016 paper neanderthal does not exceed 2.4% in western Eurasia
    p47 (SGDP samples)
    ergo its influence should could would be limited to minimal
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