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Thread: New Z251 SNPs from Full Genomes

  1. #11
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    Quote Originally Posted by seferhabahir View Post
    FGC Batch 9 results looks like October 2014 based on a recent post. Any news on your S9294 YSEQ test?
    Not yet, still waiting almost patiently.

  2. #12
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    Hello I am in signature 251-1130, do you know anything about this group. how many signature groups are associated with 251.

  3. #13
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    seferhabahir -

    I received my FGC11986 from YSEQ and I am derived (A) which backs up my Big Y result. They approximate it as R-L21 below S9294. As you recall, it was a low-confidence call in my Big Y, but it looks like YSEQ has confirmed it.

  4. #14
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    Quote Originally Posted by eastcarolinatarheel View Post
    seferhabahir -

    I received my FGC11986 from YSEQ and I am derived (A) which backs up my Big Y result. They approximate it as R-L21 below S9294. As you recall, it was a low-confidence call in my Big Y, but it looks like YSEQ has confirmed it.
    Rickwood (kit 196158) also has this SNP on order from YSEQ and perhaps he will also come back derived for FGC11986. It may be equivalent to S9294, above it or below it. We won't really know until some others who are S9294 or S11556 are confirmed negative or positive. Still, it is an interesting data point. It does not show up in Rickwood's FGC analysis of his Big Y, but he may come back positive anyway. We'll see. This SNP is defined in my FGC results as very high confidence (i.e., it appears to be a solid SNP). We could also get Crawford who is S11556+ but S9294- to test for it to see if he comes back positive or negative.

    YSEQ approximates it as below S9294 because that's how they categorized all my new SNPs. However, since you have this one also, it may not be below S9294. More results from someone who is S11556+ but S9294- will help better define it.
    Last edited by seferhabahir; 06-08-2014 at 06:27 AM.

  5. #15
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    FYI,

    Ybrowse now shows the following data for FGC11986 (there have been three people tested for this, and all three are positive). So there is at least one other person derived. I believe it is the person that ordered the package of Z251_11EE SNPs so it would make sense that this person would also be positive for FGC11986.

    count_derived: 3
    count_tested: 3
    Last edited by seferhabahir; 06-08-2014 at 06:19 AM.

  6. #16
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    Quote Originally Posted by seferhabahir View Post
    FGC Batch 9 results looks like October 2014 based on a recent post. Any news on your S9294 YSEQ test?
    Just got the results in from Astrid a few minutes ago:
    446 FGC10343 ChrY 6655119 6655124 ins-
    446 S9294 ChrY 6655208 6655208 A-

    Looks like I'm stuck at Z251 until batch #9 results come back.

  7. #17
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    Gentlemen, I would appreciate some advice. I am FT 62937, Z251+ , and as far as I know, of Scottish descent for at least 300+ years.

    My STR markers are only to the 25 level, since these were all that were available at the time. I would like to make more progress but I have no information at all about 11556, S9294, FGC11986, or any of the other SNPs downstream of Z251, apart from 555 and 583 which seem to be quite far downstream.

    My question is how I should spend limited resources, to increase STR testing to 67, or to continue down the SNP route?

    My uninformed gut feeling is that the SNP route will take me closer to my objective of finding out how my family name connects with the clan of the same name and possible Caithness, Viking or Normandy origins. Furthermore, my 25 markers rarely find close matches and it seems that certain markers are off-modal for most groupings. My na´ve thought to date is that if, at 25 markers, there is differentiation, why do I need more resolution?

    On the other hand, I recognise that researchers tend to dismiss candidates with limited STR data because they do not contribute much to the bigger picture.

    As a general comment, there may be many people in my position who followed the STR marker testing followed by FTDNA deep clade testing, then, finding themselves as L21, have spent money to find the SNP downstream of DF13 to which they belong. The people who did this now find themselves in a position where there is almost no information on Z251 sub-clades to provide an informed opinion on how to proceed. This lack of information on STR /SNP fingerprints and geographical origins must cause possible candidates to defer further testing, thus holding up the general progress of understanding.

    I suppose the bottom line of this request is what test should I invest in next and what is the reasoning behind that?

  8. #18
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    Hi Peter.

    Some folks have different opinions on the best approach, but if you have limited funds for DNA testing then my suggestion would be to test out to 67 and then eventually 111 markers before doing further SNP testing. At this time, the relative positions of some of the SNPs coming out of the next-generation sequencing tests have not been determined. Thus, in the interim, I would suggest the STR testing. You may find that you match one of the STR groups which would point you toward one of the new SNPs. You could then always test one or more SNPs individually. As you may also know, the FTDNA tree is a mess right now so this would also give time for that to be worked out. It's also possible they may come out with a newer version of their Deep Clade test at some point so that's another reason to do the STR upgrade now and then wait on the additional SNP testing. I am a big proponent of SNP testing, but after one has upgraded to at least 67 markers.

    Just my two cents.

  9. The Following User Says Thank You to eastcarolinatarheel For This Useful Post:

     Peter (06-12-2014)

  10. #19
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    Quote Originally Posted by seferhabahir View Post
    We could also get Crawford who is S11556+ but S9294- to test for it to see if he comes back positive or negative.
    Are you in touch with Crawford? Do you think he would order it? That would be key to helping determine the position if he's S9294-.

  11. #20
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    Quote Originally Posted by eastcarolinatarheel View Post
    Are you in touch with Crawford? Do you think he would order it? That would be key to helping determine the position if he's S9294-.
    We should wait to see if Rickwood who is S9294+ comes back negative for FGC11986 because that would indicate FGC11986 is below S9294 and there would be no need to test Crawford.

    [Edit: I just found out that Rickwood is indeed FGC11986+ so the next steps would be to see if Crawford or someone else that is S9294- tests positive]
    Last edited by seferhabahir; 06-10-2014 at 02:02 AM. Reason: YSEQ result has been delivered

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