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Thread: KLOTHO gene and intelligence

  1. #1
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    KLOTHO gene and intelligence

    Together with a large group of collaborators, Mucke and Dubal examined the question in three separate cohorts of people participating in aging studies of various kinds, adding up to more than 700 people. Their analysis showed that people with one of the life-extending variants of the KLOTHO gene scored better on cognitive tests
    Reference: http://www.sciencedaily.com/releases...0508121343.htm

    Relevant SNP: Rs9536314

    http://www.snpedia.com/index.php/Rs9536314

    Beneficial variants: GG, GT

    My variant: GT

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     Gray Fox (01-31-2016),  Little bit (05-08-2014),  Sangarius (05-09-2014),  Theramster (08-10-2016)

  3. #2
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    H11a2a>C12014T

    United States of America Netherlands Isle of Man Scotland Poland Northern Ireland
    Dang, I am just TT, Wife's brother is GT and her son is GG.

    life-extending variants of the KLOTHO gene scored better on cognitive tests as you get older, right?

    MJost
    148326, FGC-0FW1R, YSID6 & YF3272 R-DF13>FGC5494>*7448>*5496>*5521>*5511>*5539>*5538>* 5508>*5524
     
    Watterson USA GD1/67 & GD3/111, *5508+. GD1ís fatherís sister-23andme pred. 3rd Cous w/ 0.91% DNA shared-3 seg. Largest on Chr1 w/non-Euro admix affirms my NPE paternal Watterson line via aDNA & YDNA. A 2nd pred. 4th cous has same DKA b. 1840's Georgia and MDKA d 1703 IOM. 3rd Cousin FtDNA FF is from the Watterson Ala. *5538+ b. IOM w/ GD6/67 & GD8/111 -SGD3. FGC5539+ a Scot-Ross GD13/111 -SGD8

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  5. #3
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    In my group of 8:

    2 TT
    5 GT - including me
    1 GG

    The Mendel's are both TT

    Looking at dbSNP, GG is the least common version, less than 10% in all populations. If the G is so good, why isn't it more favored? Could there be a hidden dark side?
    http://www.ncbi.nlm.nih.gov/SNP/snp_...i?rs=rs9536314
    My Gedmatch kits: M102536 (v3 upgrade); M054852 (v2); A449981 (Ancestry v1)
    Known: 87.5% UK/Ireland American Colonial; 12.5% PA Dutch Mennonites from Germany & Switzerland
    J1c3i mitochondrial ancestress was Swiss Mennonite from Conestoga, Lancaster PA

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     Gray Fox (01-31-2016)

  7. #4
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    HV4

    Read about it yesterday. My haplotype is GT.

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     Gray Fox (01-31-2016)

  9. #5
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    Also:
    People who have one copy of a variant, or form, of the KLOTHO gene, called KL-VS, tend to live longer and have lower chances of suffering a stroke whereas people who have two copies may live shorter lives and have a higher risk of stroke. In this study, the investigators found that people who had one copy of the KL-VS variant performed better on a battery of cognitive tests than subjects who did not have it, regardless of age, sex or the presence of the apolipoprotein 4 gene, the main genetic risk factor for Alzheimer's disease.

    NMDA receptors control communication at many glutamate synapses. GluN2B subunits are components of some NMDA receptors. Previous studies have shown that the presence of GluN2B at synapses is associated with changes in synaptic strength and learning and memory. In this study, the researchers found that synapses in the brains of klotho-enhanced mice had more GluN2B subunits than control mice. Treating klotho mice with a drug that selectively blocks GluN2B-containing NMDA receptors reduced their ability to perform on learning and memory tests. The results suggest that increasing the presence of GluN2B-containing NMDA receptors may be one way that klotho could enhance cognitive skills.
    http://www.eurekalert.org/pub_releas...-lgm050914.php

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  11. #6
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    " increasing the production of the GluN2B subunit in aged animals enhances memory and synaptic transmission."

    http://www.ncbi.nlm.nih.gov/pubmed/23103326

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  13. #8
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    Greater Khorasan Afghanistan Ghaznavid Dynasty Late Saffarid Dynasty Dravida Nadu Canada
    Rs9536314

    GG
    "Humanity is all one body;
    To torture another is simply to wound yourself." - Rahman Baba

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     Ashina (02-09-2016),  Gray Fox (01-31-2016),  paulgill (01-31-2016),  surbakhunWeesste (01-31-2016)

  15. #9
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    u2b2 gonur;swat

    rs9536314 G or T
    TT
    & I thought I was extraordionaire.
    Last edited by surbakhunWeesste; 01-31-2016 at 09:32 AM.

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  17. #10
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    United States Gadsden Devon Germany Bayern Northern Ireland Germany Palatinate Wales
    Rs9536314 T / T

    Well fiddlesticks..
     
    Y-DNA : R1b-P312>DF27>Z196>L176.2>Z262>SRY2627*

    mtDNA : J1c8

    Lactase Persistence: rs4988235 - AA rs182549 - TT

    EEF 49.22068981
    WHG 35.89409732
    ANE 14.88521287


    Eurogenes K7:
    WHG 61.67%
    ENF 19.35%
    ANE 15.21%


    Ysearch - ky8wb

    ftdna - 151463

    23andMe - M936999

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     paulgill (01-31-2016)

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