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Thread: Spread of SLC45a2 Recessive Mutation

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    Spread of SLC45a2 Recessive Mutation

    Hey guys, so I've been looking at the SNP files of samples from many different sites and right now I'm trying to assess where the SLC45a2 mutation that causes further depigmentation developed, so far from what I have seen, the earliest sample to have a pair of recessive alleles is the Sidelkino EHG sample and then next would be the Samara EHG sample and we also see the mutation pop up in Scandinavian Hunter Gatherers. But other EHGs such as Karelia lack the mutation as well as samples Progress but then we see Yamnaya carry it heavily and spread it amongst the Europeans. But interestingly, I noticed the Tepe Hissar sample, I2514 also had full pair mutation as well which now makes me scratch my head on where this mutation developed and was it singular source or could it have developed independently?

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    So it seems to be present in EHG, but at lower frequency than today. Is it present at all (even heterozygous) in neolithic Iran or Central Asia?
    Is SLC45a2 the one found in Anatolian farmers also? I2514 is like it's contemporaries in having a bit of Anatolian ancestry.
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    SLC24a5 mutation is the one Anatolian farmers had as well CHG had it and EHG and Iran Neolithic. My theory for this mutation’s origins is from Dzudzuana.

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    Taforalt carries Dzidzu but no derived SLC24a5.

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