What is difference between Extended HVR and HVR1, HVR2 ?

[capsian]

Hello everybody
I would ask about the difference between Extended HVR (15930-707) and HVR1 and HVR2 in testing a YSEQ ?
Is it the same ?
https://www.yseq.net/product_info.ph...01f0900431da0d
https://www.yseq.net/product_info.ph...01f0900431da0d
https://www.yseq.net/product_info.ph...01f0900431da0d

[m_etch]

Those pages show that the Extended HVR tests about 100 more markers than the combination of HVR1 and HVR2 (1,170 combined). I don't know the value of testing the additional markers but maybe some of them are associated with particular traits or predisposition to diseases. If you're just looking for support for your V25b* haplogroup then I suspect HVR1 and HVR2 combined could provide that, but you might check with YSEQ to verify.

I should add that I'm a real amateur in regards to DNA. There are surely many people here who know significantly more about it.

[capsian]

Those pages show that the Extended HVR tests about 100 more markers than the combination of HVR1 and HVR2 (1,170 combined). I don't know the value of testing the additional markers but maybe some of them are associated with particular traits or predisposition to diseases. If you're just looking for support for your V25b* haplogroup then I suspect HVR1 and HVR2 combined could provide that, but you might check with YSEQ to verify.

I should add that I'm a real amateur in regards to DNA. There are surely many people here who know significantly more about it.

Thanks you , actually i m did WGS , i will order this test Extended HVR to my dad i want to know his mtDNA

[Saetro]

Admittedly I tested elsewhere, (YSeq did not exist at the time), but in my case it's about where the haplogroup markers lie and nothing to do with the testing lab.

I originally tested just these basic HVR markers, but later extended to the full mtDNA including the coding region.
Good that I did.
My basic mtDNA haplogroup is fairly common across NW Europe, so I needed more detail.
Turns out there are several absolutely critical markers in the coding region for my major sub-clade and more again for my specific haplogroup sub clade.
That restricted my search to Britain and Ireland and then further to one region of England.
In turn that saved me wasting a lot of money on pursuing one lead on that line that was not in that region.

Looking at some academic papers that have updated analysis from HVR regions originally to later include coding region,
my experience may be relatively rare. Most people appear to have some quite good leads from just the HVR region.
Others, like me, could be greatly misled by relying on limited data.

Currently turning blue holding my breath waiting for the latest update of haplogroup.org
It's currently effectively down, undergoing maintenance for that update.

[capsian]

Admittedly I tested elsewhere, (YSeq did not exist at the time), but in my case it's about where the haplogroup markers lie and nothing to do with the testing lab.

I originally tested just these basic HVR markers, but later extended to the full mtDNA including the coding region.
Good that I did.
My basic mtDNA haplogroup is fairly common across NW Europe, so I needed more detail.
Turns out there are several absolutely critical markers in the coding region for my major sub-clade and more again for my specific haplogroup sub clade.
That restricted my search to Britain and Ireland and then further to one region of England.
In turn that saved me wasting a lot of money on pursuing one lead on that line that was not in that region.

Looking at some academic papers that have updated analysis from HVR regions originally to later include coding region,
my experience may be relatively rare. Most people appear to have some quite good leads from just the HVR region.
Others, like me, could be greatly misled by relying on limited data.

Currently turning blue holding my breath waiting for the latest update of haplogroup.org
It's currently effectively down, undergoing maintenance for that update.

Do you think test HVR isn't useful for people belonging to haplogroup HV ? especially Haplogroup H ?
Actually i know friend he is did HVR1 and he is get result mtDNA M1a

[Saetro]

I did originally want an mtDNA haplogroup badge for whatever my haplogroup was.
That is usually possible using HVR1+2

haplogroup.org can provide more information, but it's down for maintenance.
You can still access the old version at the Internet Archive’s Wayback Machine - https://web.archive.org/web/20230213...aplogroup.org/
(I am told. I have not tried it.)

mtDNA Haplogroup H is really big in western Europe (where most DNA testers ancestors came from). And there are lots and lots of subclades.
Just like Y-DNA haplogroup R1b in NW Europe, you need more detail to get more specificity.
(mtDNA H was also in NW Africa. Opinions differ as to whether that was the pathway to bring SOME H to Europe via Morocco and Spain towards the end of the last Ice Age, or whether it was taken there FROM Europe by people during the Great Migration era - Alans, Vandals and so on. My recollection is that it could well be a bit of both, depending on the exact sub clades involved. Sorry, I have not kept records on those academic papers.)

As well as getting a haplogroup badge, I was keen to have mtDNA results help with my genealogy.
Even an exact match can have Common Ancestors up to 1000 years ago, so it's often not that useful.
But at least it has provided me with something. I have been a little lucky.
It's most useful in confirming that a suspected relative is, in fact, connected. But most of that use was 2 decades ago.
These days people use autosomal, except in very specific circumstances.

[MacUalraig]

I would say even a fully sequenced mt haplogroup isn't that much use, but it is nice to know it. I still have no idea how my H5r line came to England, most H5r* is from central Europe and I'm not in the slightly more informative H5r2 which seems to have come further west. On top of that 23andMe don't quite call it but label it H5'36 so if I see that in my matches they may or may not be direct matches to me (at the level I'm interested in).

[capsian]

I would say even a fully sequenced mt haplogroup isn't that much use, but it is nice to know it. I still have no idea how my H5r line came to England, most H5r* is from central Europe and I'm not in the slightly more informative H5r2 which seems to have come further west. On top of that 23andMe don't quite call it but label it H5'36 so if I see that in my matches they may or may not be direct matches to me (at the level I'm interested in).

You right even mtfull is not used much , actually i see i have SNP subclade Haplogroup V12 (T7270C) but is confirmed my Haplogroup is V
in 23andME don't quite call it but label it just Haplogroup V

[capsian]

I would say even a fully sequenced mt haplogroup isn't that much use, but it is nice to know it. I still have no idea how my H5r line came to England, most H5r* is from central Europe and I'm not in the slightly more informative H5r2 which seems to have come further west. On top of that 23andMe don't quite call it but label it H5'36 so if I see that in my matches they may or may not be direct matches to me (at the level I'm interested in).

23andME.jpg
mtfull.jpg

My SNP Extras
C16298T! =V6b1c and V-b
T7270C= V12
A93G = I dont know