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Thread: U4a3

  1. #1
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    U4a3

    Not so many U4a3 around!

    This is my paternal grandmother's group from NE England.

    If you have this mt-DNA on any of your lines, please introduce yourself :-)

  2. #2
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    If you've tested with Family Tree DNA or one of their partners do make sure you join our haplogroup U4 project:

    http://www.familytreedna.com/public/U4mtDNA

  3. #3
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    It is from 23andMe

    So only have:

    HVR1

    16274A
    16356C
    16519C

    HVR2

    00073G
    00247A
    00263G
    00499A

    I don't see 16274A in HVR1 in any FTDNA results (U4a3) or in any of Ian Logan's GenBank entries!

    I will have a think about doing FTDNA



    Quote Originally Posted by DebbieK View Post
    If you've tested with Family Tree DNA or one of their partners do make sure you join our haplogroup U4 project:

    http://www.familytreedna.com/public/U4mtDNA
    Last edited by Solothurn; 09-30-2013 at 08:56 AM.

  4. #4
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    There are in fact four people with 16274A in the U4 project. However, they are all in different subclades: U4a2, U4b1b and U4d1. The fourth person hasn't taken the full sequence test and in this particular case we can't assign a more detailed subclade assignment. The people in the U4 project with 16274A all have additional HVR1 mutations. It may be that those positions aren't tested by 23andMe. Most of the positions that define the subclades are found in the coding region, the part of the mt genome that is sequenced in the FMS (full mitochondrial sequence) test. The coding regions are more stable than the HVR mutations (it's not called the hypervariable region for nothing!).

    You could just do the basic mtDNAPlus test for $49 (33) which would get you into the FTDNA matching database and allow you to search for matches and upload your results to Mitosearch. If you want the detailed subclade assignment you would really need the full sequence test. There are 16569 bases in the full mt genome. 23andMe test about 3000 of these so it's only a very small percentage. I would say at this stage that the FMS still has limited application for genealogical purposes because the test is still comparatively expensive. The cost of the FMS has only come down in the last couple of years and consequently the FMS database is quite small though growing at a very steady rate. However, if you're interested in contributing to the subclade discovery process and want to upload your results to GenBank then it is worth doing. FTDNA usually have special offers at Christmas so if it's something you were considering doing it would be best to wait until then.

    If you've not already done so it's worth doing the 23andMe transfer to FTDNA so that you can be included in the Family Finder database. FTDNA have a more international database than 23andMe and they seem to have more Brits in their database though at present few of us are getting much in the way of meaningful matches. That should change now that Family Finder is the cheapest autosomal test for non-Americans (23andMe charge very high shipping costs). You can find details of the transfer programme here:

    https://www.familytreedna.com/faq/answers.aspx?id=42

  5. #5
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    Thanks DebbieK

    They are in the FF and of 303 matches only 3 are U4. 1 x U4b1b1 1 x U4b1a2 and 1 U4.

    The U4 only has HVR2. Would this reveal U4a3 or would they need a FMS?

    We will probably wait for a Christmas FMS offer!

  6. #6
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    You would need a full sequence test for U4a3 as most of the mutations that define this subclade are in the coding region. The U4 with whom you have the HVR2 match would therefore need to upgrade to the full sequence if you wanted to know whether the match is genuine.

    See the FTDNA mutation list here:

    http://www.familytreedna.com/mtDNA-H...Mutations.aspx

    You can see the full mtDNA tree on Phylotree:

    http://www.phylotree.org/tree/subtree_U.htm

    FTDNA err on the side of caution and don't make mtDNA haplogroup predictions. However, sometimes the branch-defining mutations will be found in HVR1 and/or HVR2 which will allow us to predict the detailed subclade with reasonable confidence. Unfortunately that's not possible when you have a mutation that occurs in multiple subclades.

  7. #7
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    Thanks DebbieK

    Quote Originally Posted by DebbieK View Post
    You would need a full sequence test for U4a3 as most of the mutations that define this subclade are in the coding region. The U4 with whom you have the HVR2 match would therefore need to upgrade to the full sequence if you wanted to know whether the match is genuine.

    See the FTDNA mutation list here:

    http://www.familytreedna.com/mtDNA-H...Mutations.aspx

    You can see the full mtDNA tree on Phylotree:

    http://www.phylotree.org/tree/subtree_U.htm

    FTDNA err on the side of caution and don't make mtDNA haplogroup predictions. However, sometimes the branch-defining mutations will be found in HVR1 and/or HVR2 which will allow us to predict the detailed subclade with reasonable confidence. Unfortunately that's not possible when you have a mutation that occurs in multiple subclades.

  8. #8
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    I have U4d.
    Maternal line: U4 Mesolithic
    Paternal line (father): E1b1b1a2* (E-V13) Neolithic Greco-Balkanic
    Paternal grandmother: U5a1 Mesolithic

    Eurogenes K13 Oracle: 71.5% Greek + 28.5% North Italian
    MDLP Oracle: Tuscan

  9. #9
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    U4a1
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    U4a1b1 here

  10. #10
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    I have U4a3 and would love to know more about what that means about the people I come from and any health risks or benefits.

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