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Thread: Need help with U1c

  1. #1
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    Need help with U1c

    My mom tested U1c with 23andme. I appreciate any info on likely origins and current distribution.

    23andme gives example populations as Indians,Semai, Daic.
    Last edited by Kurd; 12-31-2014 at 10:39 AM.

  2. #2
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    U5a2a1

    In the newest version of Phylotree U1c has been renamed to U1a2. If you upload her 23andMe mtDNA results to James Lick's mthap tool, it will give you a list of any extra mutations found in her test results, and if you share them with me, I will compare extra mutations with full sequence samples found in GenBank and the FTDNA U1 project.

  3. The Following User Says Thank You to GailT For This Useful Post:

     Kurd (12-31-2014)

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    Quote Originally Posted by GailT View Post
    In the newest version of Phylotree U1c has been renamed to U1a2. If you upload her 23andMe mtDNA results to James Lick's mthap tool, it will give you a list of any extra mutations found in her test results, and if you share them with me, I will compare extra mutations with full sequence samples found in GenBank and the FTDNA U1 project.
    Great, thank you Gail !

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    Quote Originally Posted by GailT View Post
    In the newest version of Phylotree U1c has been renamed to U1a2. If you upload her 23andMe mtDNA results to James Lick's mthap tool, it will give you a list of any extra mutations found in her test results, and if you share them with me, I will compare extra mutations with full sequence samples found in GenBank and the FTDNA U1 project.
    Hi Gail, this is what I got back:

    mthap version 0.19a (2013-04-08); haplogroup data version PhyloTree Build 16 (2014-02-19)
    raw data source genome_Shukria_Ali_Mito_20141231090123.txt (67K
    Found 3270 markers at 3268 positions covering 19.7% of mtDNA.

    Markers found (shown as differences to rCRS):

    HVR2: 73G 152C 263G 285T
    CR: 750G 1438G 2218T 2706G 4769G 7028T 8860G 11467G 11719A 12136C 12308G 12372A 12879C 13104G 13145A 14364A 14766T 15954C
    HVR1: 16129A 16249C 16259T 16360T (16519C)
    IMPORTANT NOTE: The above marker list is almost certainly incomplete due to limitations of genotyping technology and is not comparable to mtDNA sequencing results. It should not be used with services or tools that expect sequencing results, such as mitosearch.

    Best mtDNA Haplogroup Matches:
    1) U1a2
    Defining Markers for haplogroup U1a2:
    HVR2: 73G 263G 285T 455.1T
    CR: 750G 1438G 2218T 2706G 4769G 7028T 8860G 11467G 11719A 12136C 12308G 12372A 12879C 13104G 14070G 14364A 14766T 15148A 15326G 15954C
    HVR1: 16129A 16189C 16249C
    Marker path from rCRS to haplogroup U1a2 (plus extra markers):
    H2a2a1(rCRS) ⇨ 263G ⇨ H2a2a ⇨ 8860G 15326G ⇨ H2a2 ⇨ 750G ⇨ H2a ⇨ 4769G ⇨ H2 ⇨ 1438G ⇨ H ⇨ 2706G 7028T ⇨ HV ⇨ 14766T ⇨ R0 ⇨ 73G 11719A ⇨ R ⇨ 11467G 12308G 12372A ⇨ U ⇨ 285T 12879C 13104G 14070G 15148A 15954C 16249C ⇨ U1 ⇨ 2218T 14364A 16189C ⇨ U1a ⇨ 455.1T 12136C 16129A ⇨ U1a2 ⇨ 152C 13145A 16259T 16360T (16519C)
    Imperfect Match. Your results contained differences with this haplogroup:
    Matches(22): 73G 263G 285T 750G 1438G 2218T 2706G 4769G 7028T 8860G 11467G 11719A 12136C 12308G 12372A 12879C 13104G 14364A 14766T 15954C 16129A 16249C
    Extras(4): 152C 13145A 16259T 16360T (16519C)
    No-Calls(2): 14070G 15148A
    Untested(3): 455.1 15326 16189

    2) U1a
    Defining Markers for haplogroup U1a:
    HVR2: 73G 263G 285T
    CR: 750G 1438G 2218T 2706G 4769G 7028T 8860G 11467G 11719A 12308G 12372A 12879C 13104G 14070G 14364A 14766T 15148A 15326G 15954C
    HVR1: 16189C 16249C
    Marker path from rCRS to haplogroup U1a (plus extra markers):
    H2a2a1(rCRS) ⇨ 263G ⇨ H2a2a ⇨ 8860G 15326G ⇨ H2a2 ⇨ 750G ⇨ H2a ⇨ 4769G ⇨ H2 ⇨ 1438G ⇨ H ⇨ 2706G 7028T ⇨ HV ⇨ 14766T ⇨ R0 ⇨ 73G 11719A ⇨ R ⇨ 11467G 12308G 12372A ⇨ U ⇨ 285T 12879C 13104G 14070G 15148A 15954C 16249C ⇨ U1 ⇨ 2218T 14364A 16189C ⇨ U1a ⇨ 152C 12136C 13145A 16129A 16259T 16360T (16519C)
    Imperfect Match. Your results contained differences with this haplogroup:
    Matches(20): 73G 263G 285T 750G 1438G 2218T 2706G 4769G 7028T 8860G 11467G 11719A 12308G 12372A 12879C 13104G 14364A 14766T 15954C 16249C
    Extras(6): 152C 12136C 13145A 16129A 16259T 16360T (16519C)
    No-Calls(2): 14070G 15148A
    Untested(2): 15326 16189

    3) U1
    Defining Markers for haplogroup U1:
    HVR2: 73G 263G 285T
    CR: 750G 1438G 2706G 4769G 7028T 8860G 11467G 11719A 12308G 12372A 12879C 13104G 14070G 14766T 15148A 15326G 15954C
    HVR1: 16249C
    Marker path from rCRS to haplogroup U1 (plus extra markers):
    H2a2a1(rCRS) ⇨ 263G ⇨ H2a2a ⇨ 8860G 15326G ⇨ H2a2 ⇨ 750G ⇨ H2a ⇨ 4769G ⇨ H2 ⇨ 1438G ⇨ H ⇨ 2706G 7028T ⇨ HV ⇨ 14766T ⇨ R0 ⇨ 73G 11719A ⇨ R ⇨ 11467G 12308G 12372A ⇨ U ⇨ 285T 12879C 13104G 14070G 15148A 15954C 16249C ⇨ U1 ⇨ 152C 2218T 12136C 13145A 14364A 16129A 16259T 16360T (16519C)
    Imperfect Match. Your results contained differences with this haplogroup:
    Matches(18): 73G 263G 285T 750G 1438G 2706G 4769G 7028T 8860G 11467G 11719A 12308G 12372A 12879C 13104G 14766T 15954C 16249C
    Extras(8): 152C 2218T 12136C 13145A 14364A 16129A 16259T 16360T (16519C)
    No-Calls(2): 14070G 15148A
    Untested(1): 15326

  6. #5
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    I responded with a personal message - feel free to reply here. U1a2 is extremely rare (only 2 know full sequence samples, Azeri and Jewish) and extremely old, perhaps about 15,000 years so full mtDNA sequences are needed to better define this group and determine how closely you are related to others in this group. It would be great if your 23andMe matches also used James Lick's mthap to analyze their results in more detail, and even beter if they would the full sequence.

  7. The Following User Says Thank You to GailT For This Useful Post:

     Kurd (01-01-2015)

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