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Thread: DNA from Ancient Human in Romania shows Recent Neanderthal Ancestry

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    DNA from Ancient Human in Romania shows Recent Neanderthal Ancestry

    https://www.genomeweb.com/genetic-re...rthal-ancestry

    An international team has discovered recent Neanderthal ancestry in an ancient jaw sample from a modern human who lived in present-day Romania roughly 37,000 to 42,000 years ago, attendees heard at the Biology of Genomes meeting.

    The finding clashes with the notion that most mixing between modern humans and Neanderthals occurred in the Middle East shortly after humans migrated out of Africa, explained Qiaomei Fu, a researcher affiliated with the Max Planck Institute for Evolutionary Anthropology, the Chinese Academy of Sciences, and Harvard Medical School. Fu presented the work during a session on evolutionary and non-human genomics here today.

    Instead, genetic patterns in the ancient human hint at the potential of admixture between modern humans and Neanderthals in Europe that may have persisted until not long before Neanderthals disappeared from the continent some 40,000 years ago....

    In this case, she and her colleagues focused on DNA from a mandible found at the Pestera cu Oase site in Romania..

    In particular, Fu said, roughly half of the Oase 1 individual's chromosome 12 sequence coincided with Neanderthals rather than modern humans. Based on the SNP patterns detected in the sample, the researchers estimated that the individual had a Neanderthal ancestor within the past four to six generations, pointing to later-than-anticipated admixture between Neanderthals and the modern human population to which Oase 1 belonged...

    Meanwhile, comparisons between genetic variants in Oase 1 and those in present-day populations or previously sequenced ancient samples suggested that the ancient individual from Romania belonged to a population that ... resembled both European and Asian populations... it appears to have been far removed from agricultural populations in Europe and does not appear to have contributed much genetically to present-day human populations.

    The team is continuing to tease apart patterns from genetic profiles in the sample, including genotyping ... the Oase 1 individual's Y chromosome....
    Last edited by Jean M; 05-09-2015 at 09:50 AM.

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    More evidence of beer googles in early man

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    Quote Originally Posted by alan View Post
    More evidence of beer googles in early man
    Or maybe hallucinogenic mushroom googles as beer didnt exist

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    Is it really proven that Humans mixed with Neanderthals? Where is Neanderthal Y-DNA or mtdna ? I still think that the the so called Neanderthal admixture is just showing some archaic genetic similarities between proto-Eurasians and Neanderthals/proto-Neanderthals but not actual admixture after migration out of africa. Archaic humans often score quite high in "archaic and primitive" components like oceanian, sub-Saharan or south asian so maybe higher Neanderthal admixture among archaic humans is rather showing incomplete differentiation and "evolution" and not real Neanderthal ancestry
    Last edited by Coldmountains; 05-09-2015 at 01:22 PM.

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    Ust'-Ishim is estimated to have less Neanderthal ancestry than present-day East Asians, but in longer chunks. So whatever this is, it isn't a signal of a lack of differentiation.

    Anyway, I'm just waiting for Parasar to come along and claim that Oase 1 was a "Basal European" like Stuttgart.

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    I'm going to guess right now and say...
    MtDNA: R*
    YDna: F*

    D-stats...
    Chimp;African - Oase;Anybody....will be significantly positive
    African;UstIshim - Oase;ENF...will be insignificant
    African;Oase - WHG;Han...will be borderline significantly negative
    African;Oase - K14;Han...a little more negative than above
    African;Oase - WHG;Papuan...will be insignificant

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    This seems to prove that mixture with Neanderthals happen more than once and in regional areas. There appears to have been a homogenizing factor in Europeans though. The data is scant, but we see people such as Oetzi with higher Neanderthal. Also, the fact that both Ust-Ishim and K14 had presumed admixture that dated to the same timeframe while Oase-1 has relatively recent admixture goes to show that the admixture is indeed very real and not the by-product of archaic shared structure.

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    In the article they say Oase-1 was "....already somehow European", but distant from Neolithic Europeans. Obviously he of the Crown Eurasian branch, and related or ancestral to the "West Eurasian" branch. It seems people are missing this. He doesn't appear to be like Ush_ist but more like K14.

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    Oase-1's Y DNA will certainly come out CF. My guess is C, IJ, or P1.

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    Quote Originally Posted by Coldmountains View Post
    Is it really proven that Humans mixed with Neanderthals? Where is Neanderthal Y-DNA or mtdna ? I still think that the the so called Neanderthal admixture is just showing some archaic genetic similarities between proto-Eurasians and Neanderthals/proto-Neanderthals but not actual admixture after migration out of africa. Archaic humans often score quite high in "archaic and primitive" components like oceanian, sub-Saharan or south asian so maybe higher Neanderthal admixture among archaic humans is rather showing incomplete differentiation and "evolution" and not real Neanderthal ancestry
    This explanation has been rejected by almost everyone, although Eriksson and Manica seem to be plugging away at it.

    "The date of interbreeding between Neandertals and modern humans" - http://arxiv.org/abs/1208.2238
    "Ancient structure in Africa unlikely to explain Neanderthal and non-African genetic similarity" - http://mbe.oxfordjournals.org/conten...v.mss117.short
    Criticized in "The Doubly Conditioned Frequency Spectrum Does Not Distinguish between Ancient Popuation Structure and Hybridization"- http://mbe.oxfordjournals.org/conten.../1618.abstract
    "Neandertal Admixture in Eurasia Confirmed by Maximum-Likelihood Analysis of Three Genomes" - http://www.genetics.org/content/196/4/1241.abstract

    Patterns of linkage disequilibrium and differential selection strongly support admixture over ancestral population structure.

    As for surviving archaic uniparental lineages, well, how many modern human lineages survive from back then? Assuming the main episode of admixture happened not long before the Upper Paleolithic, as seems likely, we have C, D, F, and possibly E from Eurasia. I don't know how many mtDNA, but probably not very many. So it would be very easy for any archaic lineages to just be lost to drift - assuming there was no selective pressure against them, which there may well have been.

    It is possible that Lake Mungo 3 from Australia was carrying archaic mtDNA, though unfortunately that study was done so long ago that the results are questionable.

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