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Thread: Irish DNA Atlas, Preliminary Results

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    Irish DNA Atlas, Preliminary Results

    I attended an excellent (standing room only) lunchtime lecture given by Dr Gianpiero Cavalleri at the National Library of Ireland.
    He shared some insights into the progress of the Irish DNA Atlas Project and preliminary results.
    Below is a summary of my notes:
    1) Autosomal DNA analysis
    2) 30 mutations per generation approx
    3) Referenced Genes mirror geography in Europe, Novembre et al 2008
    4) Referenced POBI, Leslie et al 2015
    5) POBI 4060 samples
    7) Referenced Population Transformations in Europe, Haak et al 2015
    8) Referenced Large scale recent expansion of European , Batini et Al, 2015
    9) Referenced The Y Tree bursts into life , Hallast et Al, 2014

    173 samples to date
    142 sequenced FGS ?
    Strict criteria 8 great grand parents from same locality 30 km radius
    Average age 61
    Average time great grand parent lived 1848
    More sample required in Midlands, Shannon and three other areas

    Atlas follows regional organisation
    Connaught Highest
    Munster
    Ulster similar to POBI W Scotland
    Leinster

    Admixture analysis,
    Atlantic Europe (WE Seaboard), Blue. Highest
    North Europe, Red, next
    South Europe, Green, next
    Admixture Analysis (Atlantic Component)
    Ireland
    Britain
    France
    Spain
    Germany
    Italy

    Y Analysis by Mark Jobling
    R1b-M269. 90% ? estimated 4.5-5.6k ybp
    R1b-M222. 20% estimated 1.5k ybp

    Estimated R1b-M269 expansion Yamna Late Neolithic.
    Samples are used as reference data in other Population studies.

    Irish Traveler DNA Project distinct from General Irish Population.
    Possibly due to intermarriage.
    Estimated divergence 777 ybp, approx 1300s

    Next step compare samples to Yamna samples.
    Y analysis by Mark Jobling.
    No date for publication.

    I asked the question about possibility of ancient DNA samples in Ireland.
    Response although many bog bodies recovered, difficult to extract ancient DNA
    My interpretation of Admixture analysis sequence would suggest later expansion in Atlantic Europe, possibly by P312.

    Excellent start. Looking forward to publication.
    Last edited by Heber; 08-04-2015 at 09:48 PM.
    Gerard Corcoran
    R1b-DF21-S5456-S6166, H1C1

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  3. #2
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    Quote Originally Posted by Heber View Post
    I attended an excellent (standing room only) lunchtime lecture given by Dr Gianpiero Cavalleri at the National Library of Ireland.
    He shared some insights into the progress of the Irish DNA Atlas Project and preliminary results.
    Below is a summary of my notes:
    1) Autosomal DNA analysis
    2) 30 mutations per generation approx
    3) Referenced Genes mirror geography in Europe, Novembre et al 2008
    4) Referenced POBI, Leslie et al 2015
    5) POBI 4060 samples
    7) Referenced Population Transformations in Europe, Haak et al 2015
    8) Referenced Large scale recent expansion of European , Batini et Al, 2015
    9) Referenced The Y Tree bursts into life , Hallast et Al, 2014

    173 samples to date
    142 sequenced FGS ?
    Strict criteria 8 great grand parents from same locality 30 km radius
    Average age 61
    Average time great grand parent lived 1848
    More sample required in Midlands, Shannon and three other areas

    Atlas follows regional organisation
    Connaught Highest
    Munster
    Ulster similar to POBI W Scotland
    Leinster

    Admixture analysis,
    Atlantic Europe (WE Seaboard), Blue. Highest
    North Europe, Red, next
    South Europe, Green, next
    Admixture Analysis (Atlantic Component)
    Ireland
    Britain
    France
    Spain
    Germany
    Italy

    Y Analysis by Mark Jobling
    R1b-M269. 90% ? estimated 4.5-5.6k ybp
    R1b-M222. 20% estimated 1.5k ybp

    Estimated R1b-M269 expansion Yamna Late Neolithic.
    Samples are used as reference data in other Population studies.

    Irish Traveler DNA Project distinct from General Irish Population.
    Possibly due to intermarriage.
    Estimated divergence 777 ybp, approx 1300s

    Next step compare samples to Yamna samples.
    Y analysis by Mark Jobling.
    No date for publication.

    I asked the question about possibility of ancient DNA samples in Ireland.
    Response although many bog bodies recovered, difficult to extract ancient DNA
    My interpretation of Admixture analysis sequence would suggest later expansion in Atlantic Europe, possibly by P312.

    Excellent start. Looking forward to publication.
    Interesting, I presume that this project is comparing autosomal DNA of Irish samples to European datasets, in a similar way to the POBI project?

    Did the lecture say anything about genetic variation within Ireland? For instance, we know that Ulster clusters with SW Scotland so geographically we might expect southern parts of Ireland to show some affinity with Cornwall/Wales/Brittany?

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    Hopefully it will have the breakdown that was done in the PoBI study. Ireland clusters a bit north of England on genetic plots and most Irish results I've seen on Gedmatch have a pull to West Scots/Orcadian so it should be interesting to get any information on this. I hope they release some preliminary results shortly so people can get a bit of a look.

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    Quote Originally Posted by avalon View Post
    Interesting, I presume that this project is comparing autosomal DNA of Irish samples to European datasets, in a similar way to the POBI project?

    Did the lecture say anything about genetic variation within Ireland? For instance, we know that Ulster clusters with SW Scotland so geographically we might expect southern parts of Ireland to show some affinity with Cornwall/Wales/Brittany?
    The approach was similar to the POBI approach although he referenced more recent papers eg Haak et al and Hallest et al.
    The european populations PCA analysis appeared to be the same as used by POBI eg "Genes mirror geography in Europe, Novembre et al 2008"
    Although he did give an overview of POBI he did not go into detail of regional comparisons with the UK except for highlighting the Ulster Scotland connection.
    We have invited IDA to present at Genetic Genealogy Ireland in October and we expect further analysis at that stage.
    The dominant admixture component in Irish regions was the Atlantic (WE Seaboard) component with highest (my visual observation) in
    Connacht
    Munster
    Ulster
    Leinster
    Connacht and Munster were quiet close.
    I did not take photos however I believe a podcast may be in preparation.
    Regarding Y analysis which is underway by Mark Jobling my understanding is that R1b-M269 expanded in Yamnaya in the late Neolithic with possible later expansion of R1b-P312 in the Atlantic region.
    I would expect Mark Jobling to publish a combined POBI and IDA analysis of Y later this year.
    Gerard Corcoran
    R1b-DF21-S5456-S6166, H1C1

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    Quote Originally Posted by Heber View Post
    The approach was similar to the POBI approach although he referenced more recent papers eg Haak et al and Hallest et al.
    The european populations PCA analysis appeared to be the same as used by POBI eg "Genes mirror geography in Europe, Novembre et al 2008"
    Although he did give an overview of POBI he did not go into detail of regional comparisons with the UK except for highlighting the Ulster Scotland connection.
    We have invited IDA to present at Genetic Genealogy Ireland in October and we expect further analysis at that stage.
    The dominant admixture component in Irish regions was the Atlantic (WE Seaboard) component with highest (my visual observation) in
    Connacht
    Munster
    Ulster
    Leinster
    Connacht and Munster were quiet close.
    I did not take photos however I believe a podcast may be in preparation.
    Regarding Y analysis which is underway by Mark Jobling my understanding is that R1b-M269 expanded in Yamnaya in the late Neolithic with possible later expansion of R1b-P312 in the Atlantic region.
    I would expect Mark Jobling to publish a combined POBI and IDA analysis of Y later this year.
    Can you possibly elaborate on what Atlantic (WE Seaboard) means? In the PoBI study they used descriptions such as FRA17, GER6 as per the example below. I really hope that this study will use similar terminology.


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    Quote Originally Posted by Jessie View Post
    Can you possibly elaborate on what Atlantic (WE Seaboard) means? In the PoBI study they used descriptions such as FRA17, GER6 as per the example below. I really hope that this study will use similar terminology.

    He showed this slide so I guess he is following a similar methodology.
    At this early stage he showed three main admixture components
    Atlantic (WE Seaboard)
    North Europe
    South Europe
    Atlantic was the dominant component in Ireland.
    It may be that subsequent detailed analysis will include higher granularity.
    Gerard Corcoran
    R1b-DF21-S5456-S6166, H1C1

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    In the POBI paper the FRA14 dataset was apparently taken from a hospital in Rennes so I guess this probably best represents an Atlantic component. Would be interesting to know the sample locations used by the Irish DNA project.

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    Quote Originally Posted by Heber View Post
    He showed this slide so I guess he is following a similar methodology.
    At this early stage he showed three main admixture components
    Atlantic (WE Seaboard)
    North Europe
    South Europe
    Atlantic was the dominant component in Ireland.
    It may be that subsequent detailed analysis will include higher granularity.
    Thank you for these updates. I'm really looking forward to when more details are released.

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    Any idea when a paper will be released etc? Also what size SNP chip were they using. Obviously with average age of 61 for participants and average time "great grandparent lived" at 1848, it gives a snapshot into generation that survived the Great Famine (1847 obviously remembered as infamous "Back 47")

    A similiar result for Connacht/Munster make sense given that both provinces remained as majority Irish speaking provinces until at least the Famine period, Leinster obviously had most admixture over the preceeding 800 years.
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    I would hope that the SNP chip would at least have a bit of wider SNP choice than just M269 and M222 when it comes to Y-Chromosome
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