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Thread: Pain tolerance SNPs - OPRM1 gene

  1. #1
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    Pain tolerance SNPs - OPRM1 gene

    Covered this topic on my blog (here) based on a recent paper on the OPRM1 gene, which is implicated in a key opioid receptor (original article here).

    The "main" SNP (or at least the one with the greatest amount of research weight behind it) is rs1799971. The G allele is associated with increased pain sensation. A lot of the other SNPs shown in the article aren't covered by 23andMe (v2).

    Pain sensitivity is (at the least) a polygenetic trait, so your status per this SNP doesn't necessarily have to match your phenotype.

    I'm AA at rs1799971 (no increased pain sensation). How does everyone else stack up on this SNP?

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  3. #2
    J Man
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    Quote Originally Posted by DMXX View Post
    Covered this topic on my blog (here) based on a recent paper on the OPRM1 gene, which is implicated in a key opioid receptor (original article here).

    The "main" SNP (or at least the one with the greatest amount of research weight behind it) is rs1799971. The G allele is associated with increased pain sensation. A lot of the other SNPs shown in the article aren't covered by 23andMe (v2).

    Pain sensitivity is (at the least) a polygenetic trait, so your status per this SNP doesn't necessarily have to match your phenotype.

    I'm AA at rs1799971 (no increased pain sensation). How does everyone else stack up on this SNP?
    All of my family members that have tested and myself are AA.

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    I too am 'AA'
    -for what ever its worth, I have a pretty high tolerance for pain, I believe my Mom had it too...not sure if its just from having to deal with some chronic issues and you get 'used' to it, or if it has other elements such as genetics

    "OPRM1 154360797 rs1799971 A or G AA"

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    Quote Originally Posted by DMXX View Post
    Covered this topic on my blog (here) based on a recent paper on the OPRM1 gene, which is implicated in a key opioid receptor (original article here).

    The "main" SNP (or at least the one with the greatest amount of research weight behind it) is rs1799971. The G allele is associated with increased pain sensation. A lot of the other SNPs shown in the article aren't covered by 23andMe (v2).

    Pain sensitivity is (at the least) a polygenetic trait, so your status per this SNP doesn't necessarily have to match your phenotype.

    I'm AA at rs1799971 (no increased pain sensation). How does everyone else stack up on this SNP?
    rs1799971 - AA

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    rs1799971 - AA

    I was doing push-ups and weight training a few weeks after I broke my clavicle (complete break, one piece sitting atop the other). So yeah...
     
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    I'm blessed by kassitic allah with decent pain tolerance. The only time I gave in to pain. Was when I had an extreme case of charley horse in middle of the night. It feelt like my calf was being torn apart.

    I am AA for this.
    Last edited by Arbogan; 09-23-2015 at 07:55 PM.

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    Seems I'm AA as well.

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    Half my family are AA and half are AG.

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    Quote Originally Posted by evon View Post
    Half my family are AA and half are AG.
    Excellent! Glad to hear not all of us come from over-hardened quasi-masochistic genetic backgrounds.

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  19. #10
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    Well, I just checked on 5 other Somalis whose raw data the Sheikh has and they're all AA as well.

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