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Thread: Student Conducting Allergy Research

  1. #1
    Junior Member
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    Location
    California

    Student Conducting Allergy Research

    To Whom It May Concern:

    I have extremely severe allergies to cashews, pistachios, and papayas, and milder allergies to avocados and cats. As a result, I have always been very curious about allergies, and I have conducted multiple projects investigating them. This year, I am conducting a private independent science fair project on correlations between genetic mutations and allergies (specifically, food allergies). I have reached out to numerous institutions, but no one has been able to provide me with genetic data and allergies for the same people. I cannot use a public online genetic database because I do not know these people's allergies.

    I have also reached out to the 23andMe community in hopes that some would be willing to share specific raw genetic data (all of which are sequenced by 23andMe and are always accessible in the "explore my raw data" tab), allergies, and gender. So far, I have received 15 sets of data. I would like more in order to increase the accuracy of my results (by analyzing a larger sample size). All display and use of data is completely anonymous, and subjects will be represented as Person 1, Person 2, etc.

    I am reaching out to the Anthrogenica community in hopes that some of you have used genomic testing and are willing to share your genotypes for the SNPs listed below and your allergies (if you have any). If you have a 23andMe account, you can also view this post at https://www.23andme.com/you/community/thread/41626/ and compile your data either by copying/taking a screenshot of the results that show up when you enter the genes (below) in the "browse-raw-data" tab or typing the genotypes for each SNP listed below. According to a few people who have sent me data, this only took them 10 minutes.

    From reading numerous scientific publications, I know that this study may not yield the most accurate results because I'm not factoring in any epigenetic/environmental influences. However, I am accounting for that as a source of error, and I plan to include it for future research.

    To summarize -- I would need a list of your gender, allergies (if applicable), and genotypes for the SNPs of the genes I am looking at (please see below). If you would be willing to participate in this or have any questions, please email [email protected] or send me a message on Anthrogenica.

    I really appreciate your time. Thank you very much!

    Sincerely,

    Aishani Aatresh


    Genes (in parentheses) and SNPs (listed below each gene)

    (RAD50)
    rs2244012
    rs28903085
    rs17166050
    rs28903088
    rs10479007
    rs2706364
    rs2897443
    rs2522390
    rs28903092
    rs6884762
    rs2522391
    rs2301713
    rs17772565
    rs17772583
    rs3798134
    rs6871536
    rs2237060
    rs2040704
    rs2074369
    rs2240032

    (FCER1A)
    rs2247584
    rs2427824
    rs2427825
    rs7548864
    rs2427827
    rs2251746
    rs2298804
    rs2298805
    rs2252226
    rs7549785

    (FCER2)
    rs28364072
    rs2277991
    rs17159840
    rs12971845
    rs11260013
    rs11668338
    rs2277989
    rs7246264
    rs7249320
    rs2228137
    rs2287866
    rs10415518
    rs12984870
    rs2287867
    rs11672993
    rs11672997
    rs1990975

    (GATA2)
    rs3803
    rs45598538
    rs2713604
    rs2713603
    rs11717152
    rs2335052
    rs2860228

    (STAT6)
    rs4559
    rs1059513
    rs703817
    rs324015
    rs3024974
    rs841718
    rs3024971
    rs3024952
    rs324011
    rs167769

    (FOXP3)
    rs28935477
    i5003779
    i5003777
    i5003780
    rs2280883
    i5003776
    rs11465476
    rs11465472
    rs12843496
    rs3761549
    rs3761548
    rs3761547

    (CD4)
    rs11064393
    rs2707212
    rs2707210
    rs2857234
    rs2707209
    rs1075835
    rs743600
    rs10849517
    rs1894290
    rs2255301
    rs7957426
    rs11064404
    rs11064410
    rs10774450
    rs10774451
    rs11575098
    rs28917505
    rs10849524
    rs3782736
    rs28919570
    rs1055141
    rs3213427
    rs3829972
    rs28990969
    rs1045261
    rs28990972

    (TGFB1)
    rs11466358
    rs11551225
    rs8179181
    rs11466338
    rs8110090
    rs11466334
    rs1800472
    rs35383147
    rs72480424
    i5900464
    i5005333
    i5005334
    rs4803455
    rs11466324
    rs11466321
    rs2241715
    rs11466318
    i5005335
    rs13447341
    rs1800471
    rs36102838
    rs13306708
    rs13306706
    rs11551226

    (MRGPRX2)
    rs7126062
    rs7126313
    rs10833049
    rs11024970
    rs7104546
    rs7116312
    rs7102329
    rs10833052

    (IL4)
    rs2070874
    rs2243251
    rs2227284
    rs2227282
    rs2243266
    rs2243268
    rs2243270
    rs2243279
    rs2243282
    rs2243288
    rs2243290

    (IL13)
    rs2066960
    rs2069747
    rs1295686
    rs20541
    rs1295685
    rs848
    rs847

    (TSLP)

    rs2289276
    rs10062929
    rs11466741
    rs11466749
    rs11466750

    (Misc.)
    rs3806932

    Note: Since I don't have 10 posts yet, I'm not able to reply to private messages on Anthrogenica, so thank you in advance if you've sent over data.
    Last edited by alphaaat1; 12-30-2015 at 01:01 AM.

  2. The Following 6 Users Say Thank You to alphaaat1 For This Useful Post:

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  3. #2
    J Man
    Guest
    Interesting! I am allergic to peanuts, tree nuts and slightly also to soy and peas. I will look up these SNPs and report my results soon.

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     Awale (01-10-2016),  paulgill (12-30-2015)

  5. #3
    Junior Member
    Posts
    8
    Location
    California

    Thank you very much, J Man! I really appreciate it.
    Last edited by alphaaat1; 12-30-2015 at 05:04 AM.

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  7. #4
    Senior Member
    Posts
    409
    Sex
    Y-DNA (P)
    J2 Z515
    mtDNA (M)
    H1b2, X2e1a

    Bosnia and Herzegovina Byzantine Empire Russia Imperial Bulgaria Ottoman Empire
    I'm allergic to tons of things and would really like to help out but I was tested with FTDNA so I'll probably be missing quite a lot of thesw snps in my raw data.

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  9. #5
    Junior Member
    Posts
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    California

    @psaglav No worries at all--you can send me the genotypes for whatever SNPs you have.

    Thank you very much!

  10. #6
    J Man
    Guest
    My results for the first block of SNPs. Will do more later.

    rs2244012: AG
    rs28903085: AA
    rs17166050: AG
    rs28903088: GG
    rs10479007: AA
    rs2706364: GG
    rs2522390: AA
    rs28903092: GG
    rs6884762: CC
    rs2522391: GG
    rs2301713: CT
    rs17772565: CC
    rs17772583: AA
    rs3798134: AG
    rs6871536: CT
    rs2237060: GT
    rs2040704: AG
    rs2074369: CT
    rs2240032: CT
    rs2897443: GT

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  12. #7
    Junior Member
    Posts
    8
    Location
    California

    Hello & happy new year!

    I'd just like to throw out there - if there's anyone else who'd be willing to send me data, I'd really appreciate it. I'm still looking for data from people with and without allergies, and I'm more than happy to take data even if you do not have genotypes for all the SNPs I have listed out.

    If you have any questions, please email me at [email protected] or reply to this thread. I am currently unable to reply to private messages on Anthrogenica since I don't have 10 posts yet.

    Thank you very much! I really appreciate it.

  13. The Following 2 Users Say Thank You to alphaaat1 For This Useful Post:

     khanabadoshi (01-10-2016),  psaglav (01-10-2016)

  14. #8
    Senior Member
    Posts
    409
    Sex
    Y-DNA (P)
    J2 Z515
    mtDNA (M)
    H1b2, X2e1a

    Bosnia and Herzegovina Byzantine Empire Russia Imperial Bulgaria Ottoman Empire
    Quote Originally Posted by alphaaat1 View Post
    @psaglav No worries at all--you can send me the genotypes for whatever SNPs you have.

    Thank you very much!

    Wow, sorry, I had missed this!

    Will send them later today.

  15. #9
    Gold Class Member
    Posts
    4,480
    Sex
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    Jewish & British
    Y-DNA (P)
    J-Z18271
    mtDNA (M)
    J1c5
    Y-DNA (M)
    R-U152
    mtDNA (P)
    U7a5

    Israel Israel Jerusalem United Kingdom England Scotland Isle of Man
    Both me and my brother (we're twins) became allergic to cherries a couple of years ago, at the exact same time. After conducting all necessary tests, the diagnostic was pretty negative: Even the tiniest amounts will suffice to kill both of us (licking our fingers after touching a cherry for example). The strange part is that roughly one and a half year ago, I personally met a half-Jewish half-WASP person (from Seattle I think) who had the very same allergy and found out about it in similar circumstances.
    I'm also allergic to cats, dogs and pollen but this cherry allergy is by far the most brutal one I'm subjected to (to make things worse, cherries are my favourite fruit).
    Last edited by Agamemnon; 01-10-2016 at 02:20 PM.
    מכורותיך ומולדותיך מארץ הכנעני אביך האמורי ואמך חתית
    יחזקאל פרק טז ג-


    ᾽Άλλο δέ τοι ἐρέω, σὺ δ᾽ ἐνὶ φρεσὶ βάλλεο σῇσιν:
    κρύβδην, μηδ᾽ ἀναφανδά, φίλην ἐς πατρίδα γαῖαν
    νῆα κατισχέμεναι: ἐπεὶ οὐκέτι πιστὰ γυναιξίν.


    -Αγαμέμνων; H Οδύσσεια, Ραψωδία λ

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  17. #10
    Senior Member
    Posts
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    H1b2, X2e1a

    Bosnia and Herzegovina Byzantine Empire Russia Imperial Bulgaria Ottoman Empire
    Quote Originally Posted by alphaaat1 View Post
    @psaglav No worries at all--you can send me the genotypes for whatever SNPs you have.

    Thank you very much!
    Wow, this is taking a LONG time. But here are the ones I have so far:

    rs2522390 AA
    rs28903092 GG
    rs2522391 GG
    rs2301713 TC
    rs17772565 CC
    rs17772583 AA
    rs3798134 AG
    rs2237060 TG
    rs2247584 TG
    rs2427825 CC
    rs7548864 AG
    rs2298805 GG
    rs2252226 TT
    rs7549785 GG
    rs2277991 GG
    rs17159840 TT
    rs12971845 TT
    rs11260013 TT
    rs11668338 AG
    rs2277989 GG
    rs7246264 TT
    rs2228137 AG
    rs10415518 AA
    rs12984870 AG
    rs11672993 GG
    rs1990975 TC
    rs2713604 CC
    rs2335052 TC
    rs2860228 TC

    I'm allergic to shellfish and related foods, my doctor also warned me that I most likely was allergic to bee sting and prescribed mini cortisone shots just in case. I don't really carry them around, though. I have had chronic atypical urticaria for the last 15+ years and I also have allergic rhinitis. Also allergic asthma. It gets boring listing them all.

    Another thing related to the immune system, I have Hashimoto's thyroiditis, in which my body thinks my thyroid is a foreign object and produces antibodies to fight it.

    I'll try to post more later, my eyes are getting runny from the numbers.

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