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Thread: Lactase Persistence and the LCT 22018A gene

  1. #101
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    Quote Originally Posted by DMXX View Post
    50g? Damn, that's excessive and arguably pretty cruel.

    The few clinicians I've spoken to here in England who've performed the procedure told me 10g suffices. This randomised-control trial corroborates.

    Yeah, you can probably handle small quantities of lactose in your diet with some probiotics (l. bacilli being the main one). Cultured yoghurts and drinks like ayran/keffir/dugh (all names for the same drink) contain it, if you'd prefer not to use a pill supplement.

    With probiotic supplementation, you could probably get away with cheese and yoghurts, though anything that's mostly milk-derived will give you issues either way. Lactose-free milk is a very viable substitute.
    Yeah I agree, that’s the procedure in at least Canada.

    10 g would have been much easier on the stomach, but at least I was able to get the accurate result.

    My doctors told me the same thing Kefir is okay, there is even Ghee butter which contains very little or none at all depending the brand. My doctor told me not use the Lactaid pill more than once a week, as over using it can cause intestinal issues, so I got to be careful and plan before I consuming anything.

    I am bit lucky in that sense because I work for a Dairy company (I know ironic) and we make many Lactose Free products aside from Milk, like cheese slices, I have to test and see what my body will and will not accept, for me the main concern now is to get the right amount of Calcium, I have been playing it safe and eating vegetable and fruit sources that are high Calcium to get to the recommended amount.
    My Y Line: J2a-Z482>Y15222

    My Maternal Y: R1b-U152>Z36>?

    Other Y lines: 3x Great Grandfather on Maternal side: J2a-S25258>SK1336

  2. The Following 2 Users Say Thank You to Principe For This Useful Post:

     DMXX (12-09-2018),  rms2 (12-09-2018)

  3. #102
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    Looks like I have more rare lactose tolerant profile that is present in 10% of Some South Asian population & in Iberia & Tuscany & China & in Latino population

    rs4988243 -> CT
    nMonte3 current
    Velamas Gujarati_D Muslim_UP Tharus Punjabi_1000genomes
    1.859005 3.210341 4.491247 4.998440 6.040323

    G25 Ancients Dist 0.99 Shahr_I_Sokhta_BA3:S8728.E1.L1 65.2 Saidu_Sharif_IA_o:S7722.E1.L1 17.8 Udegram_IA:I1985 7.8 Jordanian:S_Jordanian-1 4.4 Barikot_IA:I6545 2.2 Scotland_N:I26602 Narva_Lithuania: Donkalnis6

    mtDNA mutation 309.1C 315.1C 522.1A 522.2C G8572A G8860A T11368C T16093a T16154C C16519T
    C195T

  4. #103
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    Quote Originally Posted by tipirneni View Post
    Looks like I have more rare lactose tolerant profile that is present in 10% of Some South Asian population & in Iberia & Tuscany & China & in Latino population

    rs4988243 -> CT
    Some more stats


    Qatar108-Genome 216 29 36 0.43519
    Qatar1005-All 176 20 31 0.40341

    1000 Genomes : 0.0892572

    DA125 125 ERS2374368 Kangju Tian Shan 1738 T-Y13279 T-Y13279 = FULL CC
    nMonte3 current
    Velamas Gujarati_D Muslim_UP Tharus Punjabi_1000genomes
    1.859005 3.210341 4.491247 4.998440 6.040323

    G25 Ancients Dist 0.99 Shahr_I_Sokhta_BA3:S8728.E1.L1 65.2 Saidu_Sharif_IA_o:S7722.E1.L1 17.8 Udegram_IA:I1985 7.8 Jordanian:S_Jordanian-1 4.4 Barikot_IA:I6545 2.2 Scotland_N:I26602 Narva_Lithuania: Donkalnis6

    mtDNA mutation 309.1C 315.1C 522.1A 522.2C G8572A G8860A T11368C T16093a T16154C C16519T
    C195T

  5. The Following User Says Thank You to tipirneni For This Useful Post:

     DMXX (12-11-2018)

  6. #104
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    I don't know much about that particular mutation. There was a paper I found several years ago that determined it correlated strongly with lactase persistence, but couldn't find any mechanistic evidence that the mutation itself caused it.

    Which is the derived (causative) allele, C or T?

    I'm a bit confused by my own biological make-up now, as I've been consuming organic (pasteurised non-homogenised) local cow's milk for a day now without any issues (no goat's milk at my local store and I refuse to ingest "nut milk")... I'm one of those annoying allergic people, so it's usually hard to determine what's giving me issues.

    It's not the casein, the lactose or the whey. What is it? I'm back to square one again!

  7. #105
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    Quote Originally Posted by DMXX View Post
    I don't know much about that particular mutation. There was a paper I found several years ago that determined it correlated strongly with lactase persistence, but couldn't find any mechanistic evidence that the mutation itself caused it.

    Which is the derived (causative) allele, C or T?

    I'm a bit confused by my own biological make-up now, as I've been consuming organic (pasteurised non-homogenised) local cow's milk for a day now without any issues (no goat's milk at my local store and I refuse to ingest "nut milk")... I'm one of those annoying allergic people, so it's usually hard to determine what's giving me issues.

    It's not the casein, the lactose or the whey. What is it? I'm back to square one again!
    http://kurdishdna.blogspot.com/2015/...-variants.html gives all these genes based on this article http://biologiaevolutiva.org/dcomas/...nattah2008.pdf http://www.ebd.csic.es/ECOGENES/Eaas...tar_Poster.pdf

    rare gene < 10% lp in some South Asian populations & Middle East & African & Tuscany/iberia/CEU & China/Japan & Finns (ht5 profile)

    For rs4988243 -> CT

    T is ancestral & C is the derivative that is req for persistence.

    There is also SNP that also causes LP in South Asian South India (35% of lp) (ht4 & 5 profile)

    rs3213871 -> CT

    Our part of South India is high in Milk consumption 5th after UP(real big state)/Rajasthan(high milk consumption)/Gujarat(high milk consumption)/MP(big state).
    nMonte3 current
    Velamas Gujarati_D Muslim_UP Tharus Punjabi_1000genomes
    1.859005 3.210341 4.491247 4.998440 6.040323

    G25 Ancients Dist 0.99 Shahr_I_Sokhta_BA3:S8728.E1.L1 65.2 Saidu_Sharif_IA_o:S7722.E1.L1 17.8 Udegram_IA:I1985 7.8 Jordanian:S_Jordanian-1 4.4 Barikot_IA:I6545 2.2 Scotland_N:I26602 Narva_Lithuania: Donkalnis6

    mtDNA mutation 309.1C 315.1C 522.1A 522.2C G8572A G8860A T11368C T16093a T16154C C16519T
    C195T

  8. #106
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    Quote Originally Posted by tipirneni View Post
    http://kurdishdna.blogspot.com/2015/...-variants.html gives all these genes based on this article http://biologiaevolutiva.org/dcomas/...nattah2008.pdf http://www.ebd.csic.es/ECOGENES/Eaas...tar_Poster.pdf

    rare gene < 10% lp in some South Asian populations & Middle East & African & Tuscany/iberia/CEU & China/Japan & Finns (ht5 profile)

    For rs4988243 -> CT

    T is ancestral & C is the derivative that is req for persistence.

    There is also SNP that also causes LP in South Asian South India (35% of lp) (ht4 & 5 profile)

    rs3213871 -> CT

    Our part of South India is high in Milk consumption 5th after UP(real big state)/Rajasthan(high milk consumption)/Gujarat(high milk consumption)/MP(big state).
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2253962/ paper shows


    rs4988243 -> CT present in Korean groups but not Saudi
    Kurdish site shows this is present 41% in Qatar population

    rs3213871 -> CT present in both Korean & Saudi groups
    nMonte3 current
    Velamas Gujarati_D Muslim_UP Tharus Punjabi_1000genomes
    1.859005 3.210341 4.491247 4.998440 6.040323

    G25 Ancients Dist 0.99 Shahr_I_Sokhta_BA3:S8728.E1.L1 65.2 Saidu_Sharif_IA_o:S7722.E1.L1 17.8 Udegram_IA:I1985 7.8 Jordanian:S_Jordanian-1 4.4 Barikot_IA:I6545 2.2 Scotland_N:I26602 Narva_Lithuania: Donkalnis6

    mtDNA mutation 309.1C 315.1C 522.1A 522.2C G8572A G8860A T11368C T16093a T16154C C16519T
    C195T

  9. #107
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    I am genetically lactose intolerant, milk products have caused problems for me all my life but I love cheese, yogurt, dogh, so I always took the magic pills. Recently, I have been drinking raw milk and munching on raw butter from a farm with no problems at all.
    Weird but awesome for me.

  10. #108
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    The prevalence of heterozygous and homozygous genotypes associated with lactase persistence
    according to https://www.ncbi.nlm.nih.gov/pubmed/23415628 (jewish & arab compared, arab different from more Euro Jew profile)

    Bedouin-Arabs, Ashkenazi, Iraqi Jew, Moroccan Jews
    CT, TT for -13910C/T 3%, 7%, 17% and 18%
    GA, AA for -22018G/A 3%, 17%, 17% and 18%
    nMonte3 current
    Velamas Gujarati_D Muslim_UP Tharus Punjabi_1000genomes
    1.859005 3.210341 4.491247 4.998440 6.040323

    G25 Ancients Dist 0.99 Shahr_I_Sokhta_BA3:S8728.E1.L1 65.2 Saidu_Sharif_IA_o:S7722.E1.L1 17.8 Udegram_IA:I1985 7.8 Jordanian:S_Jordanian-1 4.4 Barikot_IA:I6545 2.2 Scotland_N:I26602 Narva_Lithuania: Donkalnis6

    mtDNA mutation 309.1C 315.1C 522.1A 522.2C G8572A G8860A T11368C T16093a T16154C C16519T
    C195T

  11. #109
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    https://s3.amazonaws.com/academia.ed...use_of_a_C.pdf

    The most striking outcome of this study is the finding that
    the LCT enhancer sequence is significantly more heterogeneous in the lactase persistent Somali than in the nonpersistent members of the cohort. These findings are in dramatic contrast to the situation in Europe, where a single allele causal of lactase persistence is found, at very high frequency, in a genomic region of reduced genetic diversity, and which is a ‘‘textbook example’’ of the classical signal for a positive selective sweep. Here we argue that the increased degree of genetic diversity seen in the lactase persistent group resulting from multiple advantageous mutations is also a consequence of selection. The clustering of the lactase persistence associated variants in a single short sequence region, the fact that they
    occur on different haplotype backgrounds, and the substantial degree of genetic differentiation of this region between phenotypically distinct groups, taken together support the conclusion that these changes are of functional importance, but also suggest that the enhancer region affects LCT expression in a complex manner.

    Population group n P -14025A>G -14010G>C -14009T>G -13915T>G -13913T>C -13910C>T -13907C>G -13806A>G
    Afar 37 y 0.000 0.000 0.013 0.01 0.122 0.04 0.013 0.01 0.013 0.01 0.297 0.05 0.014 0.01
    Amhara 19 n 0.000 0.000 0.000 0.132 0.05 0.000 0.000 0.053 0.04 0.000
    Beni Amer 81 0.641 0.000 0.000 0.105 0.02 0.247 0.03 0.000 0.006 0.01 0.006 0.01 0.000
    Bedouin - Israeli 19 y 0.000 0.000 0.000 0.132 0.05 0.000 0.026 0.03 0.000 0.000
    Bedouin - Jordanian 23 0.511 0.022 0.02 0.000 0.000 0.348 0.07 0.000 0.000 0.000 0.000
    Bedouin – Saudi Arabian 47 0.591 0.011 0.01 0.000 0.000 0.479 0.05 0.011 0.01 0.000 0.000 0.000
    Druze 14 n 0.000 0.000 0.000 0.107 0.06 0.000 0.036 0.04 0.000 0.000
    Dunglawi 6 n 0.083 0.08 0.000 0.000 0.000 0.000 0.000 0.083 0.08 0.000
    N. European 55 0.801 0.000 0.000 0.000 0.000 0.000 0.618 0.05 0.000 0.000
    S. European 33 0.181 0.000 0.000 0.000 0.000 0.000 0.091 0.04 0.000 0.000
    Fulani 55 0.531 0.009 0.01 0.000 0.000 0.000 0.036 0.02 0.391 0.05 0.000 0.000
    Israeli non-Bedouin Arab 80 n 0.000 0.000 0.006 0.01 0.050 0.02 0.025 0.01 0.000 0.000 0.000
    Jaali 86 0.272 0.000 0.000 0.064 0.02 0.134 0.03 0.006 0.01 0.006 0.01 0.006 0.01 0.000
    Mambila 37 n 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000
    Palestinians 18 n 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000
    Shaigi 9 n 0.000 0.000 0.167 0.09 0.056 0.05 0.000 0.000 0.000 0.000
    Shuwa Arab 15 y 0.000 0.000 0.000 0.133 0.06 0.000 0.000 0.000 0.000
    Somali 37 0.132 0.000 0.027 0.02 0.013 0.01 0.041 0.02 0.013 0.01 0.000 0.095 0.03 0.019 0.02
    Somali (phenotyped) 109 0.132 0.000 0.005 0.01 0.014 0.01 0.050 0.01 0.000 0.018 0.01 0.055 0.02 0.009 0.02
    Wolof 59 0.293 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

    Table 3. Allele frequencies of all intron 13 variants observed in the populations genotyped. Standard error was calculated using the formula s = √(pq/2n), where n is the number of individuals genotyped. The column entitled P indicates whether the population is considered to be pastoralist (y) or not (n), or, if known, lactase persistence allele frequency (calculated from published phenotype frequency: source references; 1Holden & Mace 1997, 2data presented here, 3Arnold et al., 1980. Allele frequencies >0.05 are indicated in bold. 13730T>G is not included here as complete data is not available in all populations.
    nMonte3 current
    Velamas Gujarati_D Muslim_UP Tharus Punjabi_1000genomes
    1.859005 3.210341 4.491247 4.998440 6.040323

    G25 Ancients Dist 0.99 Shahr_I_Sokhta_BA3:S8728.E1.L1 65.2 Saidu_Sharif_IA_o:S7722.E1.L1 17.8 Udegram_IA:I1985 7.8 Jordanian:S_Jordanian-1 4.4 Barikot_IA:I6545 2.2 Scotland_N:I26602 Narva_Lithuania: Donkalnis6

    mtDNA mutation 309.1C 315.1C 522.1A 522.2C G8572A G8860A T11368C T16093a T16154C C16519T
    C195T

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