Full Y Chromosome Sequencing: Phase III Pilot

[FGC Corp]

Another point in regard to that paper is that the existing 10x Chromium software pipeline (i.e. Long Ranger) misses these structual variants. So, the existing manufacturer's software (10x Genomics) does not get all of the useful data from their own results.

Using our approach, we identified a series of rearrangements that included multiple SV elements not detected with the 10X Long Ranger SV caller.

[dtvmcdonald]

" https://doi.org/10.6084/m9.
figshare.7358480.v1. "

Interesting, potentially very interesting to me. I looked at it. At first glance, about an hour's work,
it appears that the regions of specific interest to me is just plain missing in their de novo assembly. I look for numerous
50-100 base long sequences and they were not there. Their nanopore-hg38 correspondence plot does
look reasonable on the large compared to what I got, with lots of inversions. Also, of course, I was comparing a Scot (myself)
with a Korean, and perhaps all A0 men are just different from Scots and Koreans (haplogroups R1a and D (or maybe C)).
This region is also missing in the Ashkenazy de-novo Pacbio sequence the paper mentions. They mention difficulties in satellites,
which this is.

[FGC Corp]

As I mentioned in another thread, there now is an option for a PacBio long read test, at $9300.

[FGC Corp]

Periodic update:

We have a group group for discussions of consumer genetics and science in general:

https://groups.google.com/forum/?hl=...al-discussions

[FGC Corp]

Recent feedback:

"From FGC Y Elite results we found a new twig under R1a-YP1363 (BY154594) shared with a Portuguese medieval cousin."

[FGC Corp]

We have secured a new partner.

[FGC Corp]

Batches 910045, 910048, and 910038 have been sequenced.

[FGC Corp]

Batch 910039, sequencing underway