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Thread: Living DNA Review & Results

  1. #1
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    Living DNA Review & Results

    In my case, Living DNA was definitely worth the money. That said, there were some problems with it. Before I talk about the good, I'm going to discuss the bad.

    Northern Native American ancestry fell under "Mesoamerica"

    It appears to be biased towards British ancestry. It left out continental European ancestry as either "unassigned" or it categorized some of what might be Germanic as East Anglia and Southeast England. There should be at least some amount of French and some amount of German in there. Continental Western European ancestry on paper is: 1.5% Dutch, 18.7% German, 0.2 % Spanish, 8.7% French. At around 29% Continental Europe on paper, at least something should show up. Hopefully they'll get the unassigned sorted out in the future.

    Maternal Haplogroup didn't give me anything more detailed than 23andme gave me, both just tell me T2b.

    On to the good:

    My Y-DNA result was very detailed, and at last I have my paternal haplogroup.

    It answered some significant questions about my British Isles ancestry. On paper I've got over 62% Isles ancestry. Living DNA confirms this as my majority region with 80.5% (Corrected to 69.3%). For reference to the accuracy of the results, my 4th great-grandparents from the Isles came from:
    1x Kilmuir, Easter Ross, 3x Derbyshire, 4x Nottinghamshire, 1x Staffordshire, 4x Stirling (likely originally Perthshire), 5x Perthshire, 1x Edinburgh, 2x Lincolnshire, 2x East Yorkshire, 2x Wiltshire, 2x Gloucestershire, 1x Somerset, 1x Dorset, 2x unknown England and or Wales, 8x unknown Ireland (probably Northern) and one fifth great-grandparent from Orkney. (total is 39.5/64 4th great-grandparents)

    I wanted to know how my Great-Grandmother's people spoke Welsh as their first language, when they all lived in SW England. While I have a good chunk from SW England, I also got 3.2% South Wales, when I was expecting Welsh Border. This answers it, they must have been South Welsh somewhere along the lines.

    Turns out I'm not Irish, I only got 1.9% SW Scotland and Northern Ireland. This does answer a question about my grandfather's claim that his Irish ancestors came from County Cork. I think after looking at this, that they might have only sailed from County Cork, and were Scotch Irish (originally settlers who lived in Northern Ireland)

    Instead of the 4% Eastern European I got on 23andme and AncestryDNA, I got a 3.3% from the Northwest Caucus region (Looks like southern Russia). This is interesting, because this seems to line up with my T2B assignment, and my Polish ancestry is far from certain. I'm willing to believe living DNA on this and I'll start trying to verify it with my paper trail.

    Total paper trail numbers for reference: 21.09% Scot, 19.4% English, 18.79% German, 12.5% Welsh, 9.37% Irish, 8.71% French, 6.25% Polish, 2% Native American, 1.56% Dutch, 0.19% Spanish, possibly 0.09% Norwegian. Attached are my other DNA test results for comparison.

    For the record, I'm very disappointed that I have little to no Gaelic DNA in me, but I'm happy to finally have answers to these questions, and to know the truth about who I inherited most of my genes from. If you have a large amount of British ancestry and you can't seem to figure some of it out with paper alone, I can't recommend this test enough. I think it's incredible.

    Edit: I found this in the East Anglia and South East England description: East Anglia and the Southeast are the regions of the UK most similar to Germanic populations such as Germany, Denmark and the Netherlands.
    If you have Southeast England ancestry that you didn’t expect: If you expected Germanic ancestry, then it is likely that it has been mistaken for British ancestry. If you expected British ancestry, but not East Anglian, then it is possible that you possess a slightly higher Anglo-Saxon ancestry proportion than expected and East Anglia is used to represent this.

    This certainly applies to me, having Dutch and German ancestry but no Southeast or East Anglian English ancestry. This changes my overall result to 11.2% Germanic, and 69.3% British, which is much closer to my paper trail. It's fantastic that they include this technical note with their results.
    Last edited by sktibo; 02-09-2017 at 07:11 AM.

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  3. #2
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    Quote Originally Posted by sktibo View Post
    Northern Native American ancestry fell under "Mesoamerica"
    Probably because of Mayan 1000 Genomes reference population used by LivingDNA and most of the other calculators. They might also consider Pima to be Mesoamerican.

    Quote Originally Posted by sktibo View Post
    Maternal Haplogroup didn't give me anything more detailed than 23andme gave me, both just tell me T2b.
    Have you had an FMS test at FTDNA? What does the James Lick utility give you with the 23andme raw data file?

    Quote Originally Posted by sktibo View Post
    My Y-DNA result was very detailed, and at last I have my paternal haplogroup.
    M153 is also tested by 23andme. In the old experience it shows up as R1b1b2a1a2b. The SNP ID is i3000029 and the mutation is A->T. Are you in the old experience or the new experience?

    I see that we had a discussion on your Y-DNA at 23andme at http://www.anthrogenica.com/showthre...rediction-help but I don't see that we discussed your result for i3000029.

    If you want to find a more downstream subclade the next step is BigY or WGS from Yseq.net

    The M153 group in the BigTree is at http://www.ytree.net/DisplayTree.php?blockID=757 and for YFull they are at https://www.yfull.com/tree/R-M153/
    Last edited by ArmandoR1b; 02-01-2017 at 10:37 PM.

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  5. #3
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    Quote Originally Posted by ArmandoR1b View Post
    Probably because of Mayan 1000 Genomes reference population used by LivingDNA and most of the other calculators. They might also consider Pima to be Mesoamerican.


    Have you had an FMS test at FTDNA? What does the James Lick utility give you with the 23andme raw data file?


    M153 is also tested by 23andme. In the old experience it shows up as R1b1b2a1a2b. The SNP ID is i3000029 and the mutation is A->T. Are you in the old experience or the new experience?

    I see that we had a discussion on your Y-DNA at 23andme at http://www.anthrogenica.com/showthre...rediction-help but I don't see that we discussed your result for i3000029.

    If you want to find a more downstream subclade the next step is BigY or WGS from Yseq.net

    The M153 group in the BigTree is at http://www.ytree.net/DisplayTree.php?blockID=757 and for YFull they are at https://www.yfull.com/tree/R-M153/
    I didn't try the James lick utility for mtdna, I will have to do that later today. Old 23andme experience, it just gave me a general r1b1a2a1a

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    Quote Originally Posted by sktibo View Post
    I didn't try the James lick utility for mtdna, I will have to do that later today. Old 23andme experience, it just gave me a general r1b1a2a1a
    I'm wondering if 23andme tested you for M153 after all. Do you know how to check your raw data for i3000029? I never saved the page for that but I did save the old mutation mapper URL and it will take you to the Browse Raw data page. If you go to https://www.23andme.com/you/labs/hap...ee_mut_mapper/ then search R1b1b2a1a2b then where you see i3000029 (M153) click on i3000029 and it should take you to the Browse Raw data page with your result for i3000029 under Your Genotype. Do you have a result and is it A or T?

    Edit: I found a page with an explanation on how to get to the Browse Raw Data page in old experience. It is at https://customercare.23andme.com/hc/...-your-Raw-Data
    Last edited by ArmandoR1b; 02-01-2017 at 11:21 PM.

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    Quote Originally Posted by ArmandoR1b View Post
    I'm wondering if 23andme tested you for M153 after all. Do you know how to check your raw data for i3000029? I never saved the page for that but I did save the old mutation mapper URL and it will take you to the Browse Raw data page. If you go to https://www.23andme.com/you/labs/hap...ee_mut_mapper/ then search R1b1b2a1a2b then where you see i3000029 (M153) click on i3000029 and it should take you to the Browse Raw data page with your result for i3000029 under Your Genotype. Do you have a result and is it A or T?

    Edit: I found a page with an explanation on how to get to the Browse Raw Data page in old experience. It is at https://customercare.23andme.com/hc/...-your-Raw-Data
    It's A. Strange.

    I dug up the old thread in which you helped me decipher my 23andme results... P312 was greyed out.. and I think that's upstream from m153?
    Last edited by sktibo; 02-02-2017 at 12:48 AM.

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    Quote Originally Posted by sktibo View Post
    It's A. Strange.
    Yes it is strange that you have A for M153 which is ancestral or negative. You might want to send an email to LivingDNA to have your terminal SNP rechecked. Do they provide any other information about your Y-DNA other than your terminal SNP?

    Quote Originally Posted by sktibo View Post
    I dug up the old thread in which you helped me decipher my 23andme results... P312 was greyed out.. and I think that's upstream from m153?
    P312 isn't tested in v3 or v4 which is why it is greyed out. Yes, P312 is upstream from both M153 and DF27.

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    Quote Originally Posted by ArmandoR1b View Post
    Yes it is strange that you have A for M153 which is ancestral or negative. You might want to send an email to LivingDNA to have your terminal SNP rechecked. Do they provide any other information about your Y-DNA other than your terminal SNP?


    P312 isn't tested in v3 or v4 which is why it is greyed out. Yes, P312 is upstream from both M153 and DF27.
    Here are the images of my Y-line to begin with... I get the impression that 23andme V3 Y DNA has it's problems and so if there's a discrepancy I am inclined to go with Living DNA. However, you are the expert on the subject at hand Armando. The only other info I can find are a few sections on history, migration, and coverage. If you think I should send them an email to verify the terminal SNP, then I'll do that.
    Last edited by sktibo; 02-02-2017 at 02:57 AM.

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    Hi Sktibo,

    Thanks for the details of your results, just to let you know a few things;

    1. We are obtaining a far larger reference database of samples from Europe and starting our own POBI like project in different countries across Europe, our aim is to luanch an update to this later in the year depending on quality of reference samples.

    2. We are improving our YDNA caller at the moment, for some groups it works really well others not so well. The team are busy reviewing the quality of each individual YSNP on the chip.

    Warmest Regards

    David

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  14. #9
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    Quote Originally Posted by sktibo View Post
    Here are the images of my Y-line to begin with... I get the impression that 23andme V3 Y DNA has it's problems and so if there's a discrepancy I am inclined to go with Living DNA. However, you are the expert on the subject at hand Armando. The only other info I can find are a few sections on history, migration, and coverage. If you think I should send them an email to verify the terminal SNP, then I'll do that.
    Hey Sktibo, Im not expert, but looks like your "M153", seems quite a high resolution, Basque? according to this tree on eupedia
    http://www.eupedia.com/europe/Haplog...#R1b-subclades

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    Quote Originally Posted by [email protected] View Post
    Hey Sktibo, Im not expert, but looks like your "M153", seems quite a high resolution, Basque? according to this tree on eupedia
    http://www.eupedia.com/europe/Haplog...#R1b-subclades
    It would line up with my oldest traceable paternal ancestor, for sure. Getting it double checked just to be sure

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