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Thread: Red Hair

  1. #1
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    Cool Red Hair

    The autosomal SNP rs1805008 is apparently the same thing as R160W or Arg160Trp, which is one of the "RHC" (Red Hair Color) variants on the MC1R gene. My Family Finder raw data show that I have a "TC" there. The T is the allele for red hair, but it's a recessive trait, so you have to have "TT" to actually have red hair yourself. So, though I carry the trait for red hair, I don't have red hair myself, although I did have a lot of it in my moustache and beard before everything started going gray. When I was younger I was also told that I had "red highlights" in my otherwise dark hair.

    My youngest daughter has red hair, as do three of my four grandkids, two boys and a girl, the children of my youngest son.

    Rs1805008 is not the only red hair SNP. There are several others.

    http://edition.cnn.com/video/data/2....-gene.cnn.html

    Last edited by rms2; 06-01-2013 at 11:36 PM.

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    I have CC for rs1805008.
    I seem to remember a 23andme post that listed about 6 different snp's. I can't find the particular post but from a different post it seems rs1805007 is another one.

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    ^ The following might be what you're referring to, rossa.

    The 23andMe Blog has a set of SNP's listed which code for red hair:

    Code:
    SNP	“Red Hair” Version	Alternate Name For Mutation
    rs34474212	C	S83P
    rs1805006	A	D84E
    rs11547464	A	R142H
    rs1110400	C	I155T
    rs1805007	T	R151C
    rs1805008	T	R160W
    i3002507	C	D294H
    I have absolutely none of those alleles for those SNPs. The overwhelming majority of my hair is dark brown, but there are occasional flecks of red and blonde.

    Looks like half of these are originally on MC1R, which is the main "red hair gene".

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    Quote Originally Posted by rms2 View Post
    The autosomal SNP rs1805008 is apparently the same thing as R160W or Arg160Trp, which is one of the "RHC" (Red Hair Color) variants on the MC1R gene. My Family Finder raw data show that I have a "TC" there. The T is the allele for red hair, but it's a recessive trait, so you have to have "TT" to actually have red hair yourself. So, though I carry the trait for red hair, I don't have red hair myself, although I did have a lot of it in my moustache and beard before everything started going gray. When I was younger I was also told that I had "red highlights" in my otherwise dark hair.
    I'm in exactly the same boat as you. I've even traced this by triangulating 23andme/Family Finder matches to a known ancestor from this little part of the world:

    http://en.wikipedia.org/wiki/List_of_Inner_Hebrides
     

    Other ancestral Y lines:

    E1b-M81 Ukraine (Ashkenazi)
    E1b-V13 England
    I1-M253 Ireland
    I2-M423 Ukraine
    R1a-L176.1 Scotland
    R1b-L584 Syria/Turkey (Sephardi)
    R1b-L20 Ireland
    R1b-L21 (1)England; (2)Wales?>Connecticut
    R1b-L48 England
    R1b-P312 Scotland
    R1b-FGC32576 Ireland

    Other ancestral mtDNA lines:

    H1b2a Ukraine (Ashkenazi)
    H6a1a3 Ukraine
    K1a9 Belarus (Ashkenazi)
    K1c2 Ireland
    V7a Ukraine

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    Quote Originally Posted by DMXX View Post
    ^ The following might be what you're referring to, rossa.

    The 23andMe Blog has a set of SNP's listed which code for red hair:

    Code:
    SNP	“Red Hair” Version	Alternate Name For Mutation
    rs34474212	C	S83P
    rs1805006	A	D84E
    rs11547464	A	R142H
    rs1110400	C	I155T
    rs1805007	T	R151C
    rs1805008	T	R160W
    i3002507	C	D294H
    I have absolutely none of those alleles for those SNPs. The overwhelming majority of my hair is dark brown, but there are occasional flecks of red and blonde.

    Looks like half of these are originally on MC1R, which is the main "red hair gene".
    Yes that looks like it, thanks.

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    Quote Originally Posted by DMXX View Post
    ^ The following might be what you're referring to, rossa.

    Code:
    SNP	“Red Hair” Version	Alternate Name For Mutation
    rs34474212	C	S83P
    rs1805006	A	D84E
    rs11547464	A	R142H
    rs1110400	C	I155T
    rs1805007	T	R151C
    rs1805008	T	R160W
    i3002507	C	D294H
    So, how do these SNPs work to produce red hair? That is, does a person need two or more of them to be present in the dominant form (i.e. an AND condition) or at least one them to be dominant? Or perhaps a combination of AND and OR?

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    Quote Originally Posted by GTC View Post
    So, how do these SNPs work to produce red hair? That is, does a person need two or more of them to be present in the dominant form (i.e. an AND condition) or at least one them to be dominant? Or perhaps a combination of AND and OR?
    I believe all you need is one of them, but since red hair is a recessive trait, you have to be homozygous to actually have red hair; having "TT" at rs1805008 is one example.

    I also believe that different red hair variants prevail in different regions. SNPedia says, for example, that rs1805008 or Arg160Trp is the one primarily responsible for red hair in Ireland.

  9. #8
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    Here is what I found from SNPedia and I have shown my alllele values

    rs1805005 GT
    Val60Leu or V60L, is a SNP in the MC1R gene associated with light blond hair color in one study. risk allele is rs1805005(T)

    rs1805006
    Asp84Glu or D84E, is one of several SNPs in the MC1R gene associated with higher risk of melanoma. risk allele is rs1805006(A)

    Allelic odds ratio for pale skin


    rs1805007 CC
    Arg151Cys or R151C, one of several SNPs in the MC1R gene associated with red hair color (redheads), and in redheaded females, linked to being more responsive to the anesthetics pentazocine, nalbuphine, and butorphanol, often used by dentists [PMID 9571181, PMID 12663858, PMID 18488028] The risk allele is rs1805007(T)

    The risk allele has also been reported in several studies to be associated with increased risk for melanoma. risk allele is (A)


    rs1805008 CC
    Arg160Trp or R160W, is one of several SNPs in the MC1R gene associated with red hair color (redheads), in this case in an Irish population. risk allele is rs1805008(T)


    rs1805009 Asp294His or D294H and located in the MC1R gene, is the most common variant associated with red hair (redheads) and poor tanning ability in one study. risk allele is rs1805009(C)


    MJost
    148326, FGC-0FW1R, YSID6 & YF3272 R-DF13>FGC5494>*7448>*5496>*5521>*5511>*5539>*5538>* 5508>*5524
     
    Watterson USA GD1/67 & GD3/111, *5508+. GD1ís fatherís sister-23andme pred. 3rd Cous w/ 0.91% DNA shared-3 seg. Largest on Chr1 w/non-Euro admix affirms my NPE paternal Watterson line via aDNA & YDNA. A 2nd pred. 4th cous has same DKA b. 1840's Georgia and MDKA d 1703 IOM. 3rd Cousin FtDNA FF is from the Watterson Ala. *5538+ b. IOM w/ GD6/67 & GD8/111 -SGD3. FGC5539+ a Scot-Ross GD13/111 -SGD8

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  11. #9
    Any frequencies for Uralic speakers?

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    Quote Originally Posted by newtoboard View Post
    Any frequencies for Uralic speakers?
    Stats on Uralic speakers as a group, or are you just asking if there are any Estonians here that can post their results?
     

    Other ancestral Y lines:

    E1b-M81 Ukraine (Ashkenazi)
    E1b-V13 England
    I1-M253 Ireland
    I2-M423 Ukraine
    R1a-L176.1 Scotland
    R1b-L584 Syria/Turkey (Sephardi)
    R1b-L20 Ireland
    R1b-L21 (1)England; (2)Wales?>Connecticut
    R1b-L48 England
    R1b-P312 Scotland
    R1b-FGC32576 Ireland

    Other ancestral mtDNA lines:

    H1b2a Ukraine (Ashkenazi)
    H6a1a3 Ukraine
    K1a9 Belarus (Ashkenazi)
    K1c2 Ireland
    V7a Ukraine

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