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Thread: The Light Skin Allele of SLC24A5 in South-Asians & Europeans Shares Identity by Desce

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    The Light Skin Allele of SLC24A5 in South-Asians & Europeans Shares Identity by Desce


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    Can you post your 23andme results?

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    I get AA on it.

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    Quote Originally Posted by MonkeyDLuffy View Post
    I get AA on it.
    Can you post your 23andme results?

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    Myself:
    Brother:
    Sister (Hanif):
    Grandmother (Balq):
    Grandmother Brother:
    Grandfather Sister (Sadia):
    Uncle (Jam):
    Aunt:
    2nd Cousin:
    Mohmand:
    Lahori:
    Multani:
    Ashkenazi:
    A/G
    A/A
    A/G
    A/A
    A/A
    A/A
    A/G
    A/A
    A/A
    A/A
    A/A
    A/A
    A/A
    “Chahar chez est tohfay Multan, Gard-o- Garma, Gada-o- Goristan”.

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    Quote Originally Posted by khanabadoshi View Post
    Myself:
    Brother:
    Sister (Hanif):
    Grandmother (Balq):
    Grandmother Brother:
    Grandfather Sister (Sadia):
    Uncle (Jam):
    Aunt:
    2nd Cousin:
    Mohmand:
    Lahori:
    Multani:
    Ashkenazi:
    A/G
    A/A
    A/G
    A/A
    A/A
    A/A
    A/G
    A/A
    A/A
    A/A
    A/A
    A/A
    A/A
    I'm surprised, could it be because of your Uzbek side?

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    Can someone explain the actual phenotype effect that this SLC24A5 is supposed to have? From what I know and see colloquially, there seems to be a difference between Europeans that can tan vs Europeans who only burn in the sun. Generally those from the Mediterranean countries can tan, while more northwesterly Europeans particularly Irish descent folks only burn. I'd imagine the Indian subcontinent light skin is the same as the Mediterranean variety. Never came across an Indian that only gets sun burn but doesn't actually darken from exposure under the sun. So shouldn't there be an actual genetic difference between the can-tan vs cannot-tan versions?

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    There was also this paper which identified rs2470102 as correlating with skin colour in south Asians.

    Abstract


    Our understanding of the genetics of skin pigmentation has been largely skewed towards populations of European ancestry, imparting less attention to South Asian populations, who behold huge pigmentation diversity. Here, we investigate skin pigmentation variation in a cohort of 1,167 individuals in the Middle Gangetic Plain of the Indian subcontinent. Our data confirm the association of rs1426654 with skin pigmentation among South Asians, consistent with previous studies, and also show association for rs2470102 single nucleotide polymorphism. Our haplotype analyses further help us delineate the haplotype distribution across social categories and skin color. Taken together, our findings suggest that the social structure defined by the caste system in India has a profound influence on the skin pigmentation patterns of the subcontinent. In particular, social category and associated single nucleotide polymorphisms explain about 32% and 6.4%, respectively, of the total phenotypic variance. Phylogeography of the associated single nucleotide polymorphisms studied across 52 diverse populations of the Indian subcontinent shows wide presence of the derived alleles, although their frequencies vary across populations. Our results show that both polymorphisms (rs1426654 and rs2470102) play an important role in the skin pigmentation diversity of South Asians.

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